Uncategorized

Dear Deidre: First time I had sex led to baby shock – The Sun

1Kk3doh
The Sun
Dear Deidre: First time I had sex led to baby shock
The Sun
I AM avoiding oral sex because I was told my cancer was caused by the HPV virus — but I do miss it. I’m 46 and my wife is 44. I was diagnosed with cancer of the tongue and neck 18 months ago. It seems to have been caught in time. I have had surgery, …

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Kk3dof
via IFTTT

Advertisements
Uncategorized

Proteomic Analysis Reveals a Novel MutS Partner Involved in Mismatch Repair Pathway Research

The mismatch repair (MMR) family is a highly conserved group of proteins that function in correcting base-base and insertion-deletion mismatches generated during DNA replication. Disruption of this process results in characteristic microsatellite instability (MSI), repair defects and susceptibility to cancer. However, a significant fraction of MSI-positive cancers express MMR genes at normal levels and do not carry detectable mutation in known MMR genes, suggesting that additional factors and/or mechanisms may exist to explain these MSI phenotypes in patients. To systematically investigate the MMR pathway, we conducted a proteomic analysis and identified MMR-associated protein complexes using tandem-affinity purification coupled with mass spectrometry (TAP-MS) method. The mass spectrometry data have been deposited to the ProteomeXchange with identifier PXD003014 and DOI 10.6019/PXD003014. We identified 230 high-confidence candidate interaction proteins (HCIPs). We subsequently focused on MSH2, an essential component of MMR pathway, and uncovered a novel MSH2-binding partner, WDHD1. We further demonstrated that WDHD1 forms a stable complex with MSH2 and MSH3 or MSH6, i.e. the MutS complexes. The specific MSH2/WDHD1 interaction is mediated by the second lever domain of MSH2 and Ala1123 site of WDHD1. Moreover, we showed that just like MSH2 deficient cells, depletion of WDHD1 also led to 6-Thioguanine (6-TG) resistance, indicating that WDHD1 likely contribute to MMR pathway. Taken together, our study uncovers new components involved in MMR pathway, which provides candidate genes that may be responsible for the development of MSI-positive cancers.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KjTgXS
via IFTTT

Uncategorized

Graham Norton pays tribute to Sir Terry Wogan: ‘He made it seem possible’ – The Independent

1PJI2Z4
The Independent
Graham Norton pays tribute to Sir Terry Wogan: ‘He made it seem possible’
The Independent
Graham Norton has paid tribute to veteran broadcaster Sir Terry Wogan, who has died aged 77 shortly after being diagnosed with cancer. Sir Terry’s broadcasting career spanned more than 50 years, and included 37 years presenting the Eurovision Song …
Sir Terry Wogan’s 10 best TV momentsTelegraph.co.uk
Legendary Irish broadcaster Terry Wogan dies aged 77 after cancer battleIrish Independent
Tributes paid to broadcasting legend Sir Terry WoganCoventry Telegraph
Hit The Floor Magazinehotpress.com
all 746 news articles »

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1SkYdmk
via IFTTT

Uncategorized

16 people a day in Yorkshire and Humber told they have cancer caused by smoking – Huddersfield Examiner

1TvkEo4
Huddersfield Examiner
16 people a day in Yorkshire and Humber told they have cancer caused by smoking
Huddersfield Examiner
While most smokers know about the link between smoking and lung cancer many people do not realise that smoking is linked with not one but 16 different cancers, including cancers of the mouth, nasal cavities, pharynx and larynx, stomach, kidney, bowel, …

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1NJWPl7
via IFTTT

Uncategorized

Teen with ultra rare tumours has leg amputated after limb swells to three times normal size – Irish Mirror

1P5zpZq
Irish Mirror
Teen with ultra rare tumours has leg amputated after limb swells to three times normal size
Irish Mirror
A brave teen has had her leg amputated after rare tumours made it grow to three times its normal size. Tia Leigh suffers from Neurofibromatosis Type I which had left her right lower limb hugely swollen, lumpy and seven centimetres longer than her left.

and more »

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QQCm4A
via IFTTT

Uncategorized

Advanced Glycation End Products Induce Obesity and Hepatosteatosis in CD-1 Wild-Type Mice

AGEs are a heterogeneous group of molecules formed from the nonenzymatic reaction of reducing sugars with free amino groups of proteins, lipids, and/or nucleic acids. AGEs have been shown to play a role in various conditions including cardiovascular disease and diabetes. In this study, we hypothesized that AGEs play a role in the “multiple hit hypothesis” of nonalcoholic fatty liver disease (NAFLD) and contribute to the pathogenesis of hepatosteatosis. We measured the effects of various mouse chows containing high or low AGE in the presence of high or low fat content on mouse weight and epididymal fat pads. We also measured the effects of these chows on the inflammatory response by measuring cytokine levels and myeloperoxidase activity levels on liver supernatants. We observed significant differences in weight gain and epididymal fat pad weights in the high AGE-high fat (HAGE-HF) versus the other groups. Leptin, TNF-α, IL-6, and myeloperoxidase (MPO) levels were significantly higher in the HAGE-HF group. We conclude that a diet containing high AGEs in the presence of high fat induces weight gain and hepatosteatosis in CD-1 mice. This may represent a model to study the role of AGEs in the pathogenesis of hepatosteatosis and steatohepatitis.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QQt2xH
via IFTTT