Health, Medicine

Biexponential T2 relaxation estimation of human knee cartilage in vivo at 3T

Purpose

To evaluate biexponential T2 relaxation mapping of human knee cartilage in vivo in clinically feasible scan times.

Materials and Methods

T2-weighted magnetic resonance (MR) images were acquired from eight healthy volunteers using a standard 3T clinical scanner. A 3D Turbo-Flash sequence was modified to enable T2-weighted imaging with different echo times. Series of T2-weighted images were fitted using mono- and biexponential models with two- and four-parametric nonlinear approaches, respectively.

Results

Biexponential relaxation of T2 was detected in the knee cartilage in five regions of interest in all eight healthy volunteers. Short/long relaxation components of T2 were estimated to be 8.27 ± 0.68 / 45.35 ± 3.79 msec with corresponding fractions of 41.3 ± 1.1% / 58.6 ± 4.6%, respectively. The monoexponential relaxation of T2 was measured to be 26.9 ± 2.27 msec. The experiments showed good repeatability with coefficient of variation root mean square (CVrms) < 18% in all regions. The only difference in gender was observed in medial tibial cartilage, where the biexponential T2 in female volunteers was significantly higher compared to male volunteers (P = 0.014). Significant differences were observed in T2 relaxation between different regions on interest.

Conclusion

Biexponential relaxation of T2 was observed in the human knee cartilage in vivo. The short and long components are thought to be related to the tightly bound and loosely bound macromolecular water compartments. These preliminary results of biexponential T2 analysis could potentially be used to increase the specificity for detection of early osteoarthritis by measuring different water compartments and their fractions.

Level of Evidence: 1

Technical Efficacy: Stage 1

J. Magn. Reson. Imaging 2017.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/2rosl8m

via IFTTT

http://ift.tt/2rolCeM

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s