Accumulation of copper and copper binding protein in periportal hepatocytes is generally considered to be an indicator of chronic cholestasis and a sign of chronic biliary pathology, particularly at an early stage when bilirubinostasis is lacking (1). Rhodanine and Orcein or Victoria blue staining methods detect copper and copper binding protein respectively. Cytokeratin 7 expression by periportal hepatocytes or hepatocyte-like cells (intermediate hepatobiliary cells) (2) is also considered an early marker of chronic cholestasis (1). It is referred to as “periportal Ker7” in the rest of this letter.
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