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JOURNAL DE PHARMACIE CLINIQUE
Volume 36, numéro 2, 2017
Retour sur la journée annuelle des internes en pharmacie

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Retrouvez l’article paru dans le Journal de Pharmacie CliniqueN°2-2017.

SOMMAIRE :
ÉDITORIAL
> L’importance du réseautage !
Aude Desnoyer, Aurélie Guérin, André Rieutord
SYNTHÈSES
> Formation et opportunités de carrières en pharmacie hospitalière : le point de vue de futurs et de jeunes diplômés du DES de pharmacie
Chloé Duran, Laura di Trapani, Christel Hosselet, Marie Lenski, Evariste Delande, Delphine Heurté, Alexandre Drezet, Jérémie Zerbit, Emmanuel Cirot, Clément Delage
> Comment le pharmacien peut-il prendre l’initiative pour coopérer avec les services cliniques ?
Marc Frachette, Véronique Zardet
> Votre temps-réponse est-il assez rapide ? Mise en œuvre d’un projet lean en pharmacie hospitalière afin de réduire le temps de préparation des ordonnances
Lise Vaillancourt, Mimi Truong
> Évaluation des technologies de santé en milieu hospitalier : organisations possibles et exemples appliqués aux dispositifs médicaux
Nicolas Martelli
> Accompagnement pharmaceutique du patient obèse à l’officine : état des lieux territorial
Audrey Decottignies, Sophie Renet, Sophie Cavalier, Guillaume Pourcher, André Rieutord
CONGRÈS
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Aurélie Chaigneau, Rémi Pieragostini, Marie Cabagnols, Clément Delage
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Acute facial nerve paralysis in children,………………………………………………………………………………………………………………………….. Bell’s palsy in an adolescent girl – not always a neurologist’s territory: A case report and review of literature by Latha M Sneha via CHRISMED Journal of Health and Research : 2014 – 1(4) Latha M Sneha, Raichel Priyanka, Shanthini Thanga Tamilselvan, Julius Xavier Scott CHRISMED Journal of Health and Research 2017 4(3):209-211 Infections, inflammatory, and autoimmune conditions are the well-recognized etiologies of acute facial nerve paralysis in children. Bell’s palsy is idiopathic peripheral facial nerve palsy. Cranial neuropathies do occur in children due to the central nervous system involvement by malignancies but uncommon in pediatric acute lymphoblastic leukemias and even rarer in acute myeloid leukemias (AMLs). We report a case of a 13-year-old girl who presented with acute facial nerve palsy, wa

The common etiology associated with acute facial nerve paralysis in children are otitis media, mastoiditis, viral infections such as herpes, varicella, mumps, HIV, meningitis, encephalitis, mycoplasma, Lyme disease, and inflammatory conditions such as vasculitis, Henoch–Schonlein purpura, Kawasaki syndrome, Gullain–Barre syndrome, and hypertension.[3]

Seventy percent of the children with acute lower motor neuron facial paralysis have a favorable prognosis and it resolves spontaneously within 3 months without any sequela. In 40%–75% of children, cause of unilateral facial paralysis is idiopathic, described as Bell’s palsy and most of them have a positive history of viral illness 2–3 weeks preceding the neurological manifestations. The use of steroids to reduce the duration of paralysis and reduce the risk of long-term impairment was based on adult studies though the benefits of steroids in children is yet to be proven.[4] Due to the self-resolving nature of the idiopathic variety of the facial palsy seen in children, the neurological manifestations of leukemia as an etiology is never thought of. Steroids, when commonly prescribed in such cases causes a partial recovery thereby masking the primary pathology and adds to the diagnostic dilemma.

The frequency of symptomatic facial palsy has been found to be higher in the younger age group when compared to the idiopathic variety.[5]

AML accounts for 15% of all leukemia and presents with symptoms of prolonged fever, hepatosplenomegaly, and skin or mucocutaneous bleeds. When focal masses of immature myeloid cells from the granulocytic lineage infiltrate the soft tissues and bones, they are called granulocytic sarcomas or chloromas and occur in 5% of cases of AML. It is postulated that the granulocytic sarcomas traverse through the haversian canals from the bone marrow and gets deposited in the subperiosteum to form soft tissue masses.[6]

Granulocytic sarcomas may manifest concurrently with the disease or during remission or relapse. However, when sarcomas precede the disease in peripheral blood or marrow, it often poses a diagnostic challenge, more so, if cranial neuropathies are caused by unidentifiable chloromas as in our case. Facial paralysis resulting from leukemic infiltration, though rare, occurs during the relapse of the disease or as a complication primary disease, but it is not a well-recognized presenting symptom of childhood leukemia. Diagnostic delays of 1 month have been reported when facial nerve palsy was the isolated manifestation of AML in children.[7] Otomastoiditis due to the leukemic infiltration of the temporal bone has been attributed to the facial nerve paralysis. MRI with contrast of the facial nerve canal helps in identifying the facial nerve enhancement. However, the clinical findings of facial nerve paralysis were not always associated with radiological findings in most of the cases.[7]

Baek et al. have reported 11 children who had facial nerve paralysis as isolated feature of AML. Brain imaging studies showed mastoiditis in four of them and chloroma was identified in five of them. Six of them did not have blast in the CSF. Facial nerve palsy improved within a mean period of 1–6 months of chemotherapy.[7] Rohit et al. have reported a case of 13-year-old girl-AML with t(8:21) positivity who presented with bilateral proptosis and facial nerve palsy.[8]

When leukemic children presented with cranial neuropathies, the treatment included systemic and intrathecal chemotherapy with whole brain irradiation. However, Baek et al. recommend allogenic bone marrow transplant, avoiding whole brain irradiation in children to reduce the development of secondary malignancies and to prevent the long-term sequelae on cognitive and endocrine function.

Due to the self-resolving nature of the idiopathic variety of facial nerve palsy, when these children present to general physicians or neurologists, the diagnosis of leukemia is overlooked. Gradual progression of the paralysis beyond 3 weeks should warrant additional investigations to rule out the etiology.

CASE REPORT
Year : 2017 | Volume : 4 | Issue : 3 | Page : 209-211

Bell’s palsy in an adolescent girl – not always a neurologist’s territory: A case report and review of literature

Latha M Sneha1, Raichel Priyanka2, Shanthini Thanga Tamilselvan2, Julius Xavier Scott3
1 Department of Pediatrics, Division of Pediatric Hemato Oncology, Sri Ramachandra University, Chennai, Tamil Nadu, India
2 Department of Pediatrics, Sri Ramachandra University, Chennai, Tamil Nadu, India
3 Division of Pediatric Hemato Oncology, Sri Ramachandra University, Chennai, Tamil Nadu, India

Date of Web Publication 13-Jul-2017

Correspondence Address:
Latha M Sneha
Division of Pediatric Hemato Oncology, Sri Ramachandra University, No. 1, Ramachandra Nagar, Porur, Chennai – 600 116, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None

Crossref citations Check

DOI: 10.4103/cjhr.cjhr_123_16

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Abstract

Infections, inflammatory, and autoimmune conditions are the well-recognized etiologies of acute facial nerve paralysis in children. Bell’s palsy is idiopathic peripheral facial nerve palsy. Cranial neuropathies do occur in children due to the central nervous system involvement by malignancies but uncommon in pediatric acute lymphoblastic leukemias and even rarer in acute myeloid leukemias (AMLs). We report a case of a 13-year-old girl who presented with acute facial nerve palsy, was being treated as Bell’s palsy elsewhere and was later diagnosed to have AML.

Keywords: Acute myeloid leukemia, Bell’s palsy, child

How to cite this article:
Sneha LM, Priyanka R, Tamilselvan ST, Scott JX. Bell’s palsy in an adolescent girl – not always a neurologist’s territory: A case report and review of literature. CHRISMED J Health Res 2017;4:209-11
How to cite this URL:
Sneha LM, Priyanka R, Tamilselvan ST, Scott JX. Bell’s palsy in an adolescent girl – not always a neurologist’s territory: A case report and review of literature. CHRISMED J Health Res [serial online] 2017 [cited 2017 Jul 14];4:209-11. Available from: http://www.cjhr.org/text.asp?2017/4/3/209/210478
Introduction Top

Acute, peripheral facial palsy can be presenting feature of infections, inflammatory, and autoimmune conditions and has a good prognosis in children. The incidence of facial paralysis in children <10 years of age is reported to be 2.7/100,000.[1] Majority of them are unilateral, idiopathic, and termed Bell’s palsy. A diagnosis of exclusion, Bell’s palsy accounts for 42%–85% of cases in children with facial nerve paralysis.[2] Although association of facial palsies in malignancies is well reported, facial paralysis is not a well-recognized presenting feature of leukemias in children, especially in acute myeloid leukemia (AML). The presence of Bell’s palsy in children warrants a complete evaluation to rule out leptomeningeal diseases. We report a case of an adolescent girl who presented with acute facial nerve palsy, treated as Bell’s palsy elsewhere and was later diagnosed to have AML.

Case Report Top

A 13-year-old girl presented with acute onset of right-sided facial nerve palsy of 2 weeks duration. She was diagnosed to have idiopathic Bell’s palsy elsewhere and was being treated symptomatically with physiotherapy and oral steroids with no improvement in symptoms. She had no constitutional symptoms of fever, anorexia or fatigue, bone pain, mucocutaneous, or skin bleeds. In view of persistent symptoms, she was referred to a higher center for further evaluation. Examination revealed a right-sided lower motor neuron facial nerve palsy [Figure 1], without hepatosplenomegaly or lymphadenopathy. Central nervous system examination and rest of the systemic examination were normal. Investigations revealed hemoglobin 5.9 g/dl, total leukocyte count 14,900/μL (polymorphs: 64.1%, lymphocytes 30.3%), and platelet count 83,000/μL. Peripheral smear revealed leukocytosis with increase in blasts (50%) with Auer rods More Details along with thrombocytopenia [Figure 2].

Figure 1: Right-sided lower motor neuron palsy

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Figure 2: Peripheral smear showing blasts with Auer rods

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Bone marrow aspiration showed hypercellular marrow with 58% blasts, promyelocytes – nil, myelocytes – 9, metamyelocytes – 9, neutrophil – 3, eosinophil – 2, band – 4, lymphocytes – 9, monocytes – nil, and plasma cells – 1 [Figure 3]. Cerebrospinal fluid (CSF) analysis was negative for malignant cells. Flow cytometry revealed blasts positive for CD33, cytoplasmic myeloperoxidase, and Human leukocyte antigen –D related (HLA-DR). Magnetic resonance imaging (MRI) brain, MRI angiogram, and venogram were normal. Cytogenetics was negative for t(8:21), inversion 16, t(9:11), and t(15:17). The girl was diagnosed as AML M0. She was started on chemotherapy and after the first cycle of chemotherapy, the bone marrow is in remission and she had partial resolution of facial nerve palsy.

Figure 3: Bone marrow aspirate showing hypercellular marrow with increased blasts 58%

Click here to view

Discussion Top

The common etiology associated with acute facial nerve paralysis in children are otitis media, mastoiditis, viral infections such as herpes, varicella, mumps, HIV, meningitis, encephalitis, mycoplasma, Lyme disease, and inflammatory conditions such as vasculitis, Henoch–Schonlein purpura, Kawasaki syndrome, Gullain–Barre syndrome, and hypertension.[3]

Seventy percent of the children with acute lower motor neuron facial paralysis have a favorable prognosis and it resolves spontaneously within 3 months without any sequela. In 40%–75% of children, cause of unilateral facial paralysis is idiopathic, described as Bell’s palsy and most of them have a positive history of viral illness 2–3 weeks preceding the neurological manifestations. The use of steroids to reduce the duration of paralysis and reduce the risk of long-term impairment was based on adult studies though the benefits of steroids in children is yet to be proven.[4] Due to the self-resolving nature of the idiopathic variety of the facial palsy seen in children, the neurological manifestations of leukemia as an etiology is never thought of. Steroids, when commonly prescribed in such cases causes a partial recovery thereby masking the primary pathology and adds to the diagnostic dilemma.

The frequency of symptomatic facial palsy has been found to be higher in the younger age group when compared to the idiopathic variety.[5]

AML accounts for 15% of all leukemia and presents with symptoms of prolonged fever, hepatosplenomegaly, and skin or mucocutaneous bleeds. When focal masses of immature myeloid cells from the granulocytic lineage infiltrate the soft tissues and bones, they are called granulocytic sarcomas or chloromas and occur in 5% of cases of AML. It is postulated that the granulocytic sarcomas traverse through the haversian canals from the bone marrow and gets deposited in the subperiosteum to form soft tissue masses.[6]

Granulocytic sarcomas may manifest concurrently with the disease or during remission or relapse. However, when sarcomas precede the disease in peripheral blood or marrow, it often poses a diagnostic challenge, more so, if cranial neuropathies are caused by unidentifiable chloromas as in our case. Facial paralysis resulting from leukemic infiltration, though rare, occurs during the relapse of the disease or as a complication primary disease, but it is not a well-recognized presenting symptom of childhood leukemia. Diagnostic delays of 1 month have been reported when facial nerve palsy was the isolated manifestation of AML in children.[7] Otomastoiditis due to the leukemic infiltration of the temporal bone has been attributed to the facial nerve paralysis. MRI with contrast of the facial nerve canal helps in identifying the facial nerve enhancement. However, the clinical findings of facial nerve paralysis were not always associated with radiological findings in most of the cases.[7]

Baek et al. have reported 11 children who had facial nerve paralysis as isolated feature of AML. Brain imaging studies showed mastoiditis in four of them and chloroma was identified in five of them. Six of them did not have blast in the CSF. Facial nerve palsy improved within a mean period of 1–6 months of chemotherapy.[7] Rohit et al. have reported a case of 13-year-old girl-AML with t(8:21) positivity who presented with bilateral proptosis and facial nerve palsy.[8]

When leukemic children presented with cranial neuropathies, the treatment included systemic and intrathecal chemotherapy with whole brain irradiation. However, Baek et al. recommend allogenic bone marrow transplant, avoiding whole brain irradiation in children to reduce the development of secondary malignancies and to prevent the long-term sequelae on cognitive and endocrine function.

Due to the self-resolving nature of the idiopathic variety of facial nerve palsy, when these children present to general physicians or neurologists, the diagnosis of leukemia is overlooked. Gradual progression of the paralysis beyond 3 weeks should warrant additional investigations to rule out the etiology.

Conclusion Top

While managing young children with acute lower motor neuron facial nerve palsy, neurologists and general physicians should have an index of suspicion for the neurological manifestations of acute leukemia and hence complete blood counts, peripheral smear and a bone marrow study if needed should be a part of the work up for etiology in such cases. The routine use of steroids may result in partial remission and can cause diagnostic delays.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References Top
1. Singhi P, Jain V. Bell’s palsy in children. Semin Pediatr Neurol 2003;10:289-97. Back to cited text no. 1
[PUBMED]
2. May M, Fria TJ, Blumenthal F, Curtin H. Facial paralysis in children: Differential diagnosis. Otolaryngol Head Neck Surg 1981;89:841-8. Back to cited text no. 2
3. Ciorba A, Corazzi V, Conz V, Bianchini C, Aimoni C. Facial nerve paralysis in children. World J Clin Cases 2015;3:973-9. Back to cited text no. 3
4. Unüvar E, Oguz F, Sidal M, Kiliç A. Corticosteroid treatment of childhood Bell’s palsy. Pediatr Neurol 1999;21:814-6. Back to cited text no. 4
5. Krishnamurthy S, Weinstock AL, Smith SH, Duffner PK. Facial palsy, an unusual presenting feature of childhood leukemia. Pediatr Neurol 2002;27:68-70. Back to cited text no. 5
6. Stein-Wexler R, Wootton-Gorges SL, West DC. Orbital granulocytic sarcoma: An unusual presentation of acute myelocytic leukemia. Pediatr Radiol 2003;33:136-9. Back to cited text no. 6
7. Baek HJ, Han DK, Kim YO, Choi IS, Hwang TJ, Kook H. Facial palsy as the presenting symptom of acute myeloid leukemia in children: Three cases with stem cell transplantations. Korean J Pediatr 2009;52:713-6. Back to cited text no. 7
8. Rohit K, Jitender MK, Atul S, Soumya S. The paradox of recurrent with rare: A rare case of bilateral proptosis and facial palsy in acute myeloid leukemia with recurrent cytogenetic translocation t(8:21). Int J Appl Basic Med Res 2015;5:76-8. Back to cited text no. 8

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480
alsfakia

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Head and Neck Diseases

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Prevalence and triggers of anaphylactic events in schools

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tzWsvr

Prevalence and triggers of anaphylactic events in schools

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tzWsvr

Seasonal variation and monthly patterns of skin symptoms in Korean children with atopic eczema/dermatitis syndrome

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2sgBY6U

Seasonal variation and monthly patterns of skin symptoms in Korean children with atopic eczema/dermatitis syndrome

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
http://ift.tt/2sgBY6U

Association of maternal depression and allergic diseases in Korean children

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tA985n

Association of maternal depression and allergic diseases in Korean children

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tA985n

A 10-year experience of a novel and safe modified environmental rush immunotherapy protocol

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2sgNQWF

A 10-year experience of a novel and safe modified environmental rush immunotherapy protocol

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2sgNQWF

Pearls and pitfalls: Autoimmune lymphoproliferative syndrome and autoimmune lymphoproliferative syndrome‐like disease

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tzJmhv

Pearls and pitfalls: Autoimmune lymphoproliferative syndrome and autoimmune lymphoproliferative syndrome‐like disease

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tzJmhv

A 28-year-old woman with fever, rash, and pancytopenia

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2sgVfVC

A 28-year-old woman with fever, rash, and pancytopenia

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2sgVfVC

For the Patient: Prevalence and triggers of anaphylactic events in schools

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2sh6JbW

For the Patient: Prevalence and triggers of anaphylactic events in schools

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
http://ift.tt/2sh6JbW

Abstracts from the New England Society of Allergy Spring Meeting, April 7, 2017, Westford, MA

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 5 ώρες
http://ift.tt/2tAls5s

Abstracts from the New England Society of Allergy Spring Meeting, April 7, 2017, Westford, MA

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2tAls5s

A call to arms of specialty societies to review the WHO International Classification of Diseases, Eleventh Revision terms appropriate for the diseases they manage: The example of the Joint Allergy Academies

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2tzN8HC

The atopic disorders and atopy … “strange diseases” now better defined!

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2sgBYUs

Atopic dermatitis treatment: Current state of the art and emerging therapies

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tA0cwW

Efficacy and safety of omalizumab in children and adolescents with moderate-to-severe asthma: A systematic literature review

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2sgPIOT

A 6-month safety and efficacy study of fluticasone propionate and fluticasone propionate/salmeterol multidose dry powder inhalers in persistent asthma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tzQtqf

Asthma in older people hospitalized with influenza in Spain: A case-control study

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2sh5NEl

Prevalence and triggers of anaphylactic events in schools

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tzWsvr

Seasonal variation and monthly patterns of skin symptoms in Korean children with atopic eczema/dermatitis syndrome

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2sgBY6U

Association of maternal depression and allergic diseases in Korean children

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tA985n

A 10-year experience of a novel and safe modified environmental rush immunotherapy protocol

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2sgNQWF

Pearls and pitfalls: Autoimmune lymphoproliferative syndrome and autoimmune lymphoproliferative syndrome‐like disease

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2tzJmhv

A 28-year-old woman with fever, rash, and pancytopenia

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
[image: aap.gif] http://ift.tt/2sgVfVC

For the Patient: Prevalence and triggers of anaphylactic events in schools

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2sh6JbW

Abstracts from the New England Society of Allergy Spring Meeting, April 7, 2017, Westford, MA

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 5 ώρες
http://ift.tt/2tAls5s

Assessment of complete unilateral cleft lip and palate treatment outcome using EUROCRAN index and associated factors

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 6 ώρες
[image: S01655876.gif] Publication date: September 2017 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 100 Author(s): Anas Imran Arshad, Mohammad Khursheed Alam, Mohd Fadhli Khamis ObjectivesAssessment of treatment outcome is the only non-invasive approach to identify the effects of cleft lip and palate repair and modify management accordingly. Here the aim is to assess the outcome of complete unilateral cleft lip and palate (CUCLP) patients using EUROCRAN index and to check whether there are any factors associated with the treatment outcome.Materials and met… περισσότερα »

Assessment of complete unilateral cleft lip and palate treatment outcome using EUROCRAN index and associated factors

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 6 ώρες
[image: S01655876.gif] Publication date: September 2017 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 100 Author(s): Anas Imran Arshad, Mohammad Khursheed Alam, Mohd Fadhli Khamis ObjectivesAssessment of treatment outcome is the only non-invasive approach to identify the effects of cleft lip and palate repair and modify management accordingly. Here the aim is to assess the outcome of complete unilateral cleft lip and palate (CUCLP) patients using EUROCRAN index and to check whether there are any factors associated with the treatment outcome.Materials and met… περισσότερα »

Can Residents Be Trained and Safety Maintained?

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 8 ώρες
Publication date: Available online 1 July 2017 *Source:*Journal of Surgical Education Author(s): Marina Gorelik, Steven Godelman, Adel Elkbuli, Lauren Allen, Dessy Boneva, Mark McKenney IntroductionTeaching hospitals and faculty need to balance the educational mission for training residents with patient safety. There are no data studying the change in trauma patient outcomes before and after implementation of a surgical residency. The objective of this study was to compare trauma center outcomes before and after the advent of a surgical training program. We predicted that patient-ce… περισσότερα »

Multiple Non-Syndromic Bilaterally Erupted Para Premolars in the Mandibular Arch: A Case Report

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 10 ώρες
Authors: Amit Mehra [1], Amit Rekhi [2] Affiliations: [1] Professor, Department of Orthodontics and Dentofacial Orthopedics, Himachal Institute of Dental Sciences, Himachal Pradesh, India [2] Senior Lecturer, Department of Public Health Dentistry, Uttaranchal Dental and Medical Research Institute, Uttarakhand, India Conflict of Interest: None declared This article has been peer reviewed. Article Submitted on: 11th […] http://ift.tt/2tB4vrk

NCI UNC Project ESCC

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 11 ώρες
*Condition*: Esophageal Squamous Cell Carcinoma *Intervention*: *Sponsor*: National Cancer Institute (NCI) *Not yet recruiting* – verified June 26, 2017 http://ift.tt/2tFbXSY

Eltrombopag for People With Fanconi Anemia

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 11 ώρες
*Condition*: Fanconi’s Anemia *Intervention*: Drug: Eltrombopag *Sponsor*: National Heart, Lung, and Blood Institute (NHLBI) *Not yet recruiting* – verified June 28, 2017 http://ift.tt/2ueJQHd

NCI UNC Project ESCC

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 11 ώρες
*Condition*: Esophageal Squamous Cell Carcinoma *Intervention*: *Sponsor*: National Cancer Institute (NCI) *Not yet recruiting* – verified June 26, 2017 http://ift.tt/2tFbXSY

NCI UNC Project ESCC

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 11 ώρες
*Condition*: Esophageal Squamous Cell Carcinoma *Intervention*: *Sponsor*: National Cancer Institute (NCI) *Not yet recruiting* – verified June 26, 2017 http://ift.tt/2tFbXSY

Eltrombopag for People With Fanconi Anemia

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 11 ώρες
*Condition*: Fanconi’s Anemia *Intervention*: Drug: Eltrombopag *Sponsor*: National Heart, Lung, and Blood Institute (NHLBI) *Not yet recruiting* – verified June 28, 2017 http://ift.tt/2ueJQHd

Eltrombopag for People With Fanconi Anemia

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 11 ώρες
*Condition*: Fanconi’s Anemia *Intervention*: Drug: Eltrombopag *Sponsor*: National Heart, Lung, and Blood Institute (NHLBI) *Not yet recruiting* – verified June 28, 2017 http://ift.tt/2ueJQHd

Contributors

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
J. REGAN THOMAS, MD, FACS http://ift.tt/2t656QX

Contributors

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
J. REGAN THOMAS, MD, FACS http://ift.tt/2t656QX

Contents

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
James B. Lucas http://ift.tt/2sBrYob

Contents

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
James B. Lucas http://ift.tt/2sBrYob

Skin and Composite Grafting Techniques in Facial Reconstruction for Skin Cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Skin and composite grafting provide effective resurfacing and reconstruction for cutaneous defects after excision of the malignancy. The goal is to restore a natural appearance and function while preventing distortion of the eyelid, nose, or lips. With careful planning and attention to aesthetic subunits, the surgeon can camouflage incisions and avoid blunting aesthetically sensitive sulci. The surgical plan is also informed by the pathology, as basal or squamous cell carcinomas removed by Mohs micrographic excision have different prognostic and logistical considerations from mela…περισσότερα »

Skin and Composite Grafting Techniques in Facial Reconstruction for Skin Cancer

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Skin and composite grafting provide effective resurfacing and reconstruction for cutaneous defects after excision of the malignancy. The goal is to restore a natural appearance and function while preventing distortion of the eyelid, nose, or lips. With careful planning and attention to aesthetic subunits, the surgeon can camouflage incisions and avoid blunting aesthetically sensitive sulci. The surgical plan is also informed by the pathology, as basal or squamous cell carcinomas removed by Mohs micrographic excision have different prognostic and logistical considerations from mela…περισσότερα »

Defect of the Eyelids

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects. http://ift.tt/2sBuCuc

Defect of the Eyelids

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects. http://ift.tt/2sBuCuc

Flap Basics III

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Paramedian forehead and melolabial flaps are the most common examples of interpolated flaps used by facial plastic surgeons and are excellent options for reconstruction of the midface after Mohs surgery. They provide superior tissue match in terms of thickness, texture, and color, while leaving minimal defects at the tissue donor sites. The main advantage of interpolated flaps is the robust blood supply, which can be either axial of randomly based, and the maintenance of the integrity of facial landmarks. The main disadvantage is the frequent need for a multistage procedure, which…περισσότερα »

Flap Basics III

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Paramedian forehead and melolabial flaps are the most common examples of interpolated flaps used by facial plastic surgeons and are excellent options for reconstruction of the midface after Mohs surgery. They provide superior tissue match in terms of thickness, texture, and color, while leaving minimal defects at the tissue donor sites. The main advantage of interpolated flaps is the robust blood supply, which can be either axial of randomly based, and the maintenance of the integrity of facial landmarks. The main disadvantage is the frequent need for a multistage procedure, which…περισσότερα »

Forthcoming Issues

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Trauma in Facial Plastic Surgery http://ift.tt/2sBt1Vb

Forthcoming Issues

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Trauma in Facial Plastic Surgery http://ift.tt/2sBt1Vb

Flap Basics II

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
A mastery of advancement flap design, selection, and execution greatly aids the surgeon in solving reconstructive dilemmas. Advancement flaps involve carefully planned incisions to most efficiently close a primary defect in a linear vector. Advancement flaps are subcategorized as unipedicle, bipedicle, V-to-Y, and Y-to-V flaps, each with their own advantages and disadvantages. When selecting and designing an advancement flap, the surgeon must account for primary and secondary movement to prevent distortion of important facial structural units and boundaries. http://ift.tt/2t6g2yl

Flap Basics II

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
A mastery of advancement flap design, selection, and execution greatly aids the surgeon in solving reconstructive dilemmas. Advancement flaps involve carefully planned incisions to most efficiently close a primary defect in a linear vector. Advancement flaps are subcategorized as unipedicle, bipedicle, V-to-Y, and Y-to-V flaps, each with their own advantages and disadvantages. When selecting and designing an advancement flap, the surgeon must account for primary and secondary movement to prevent distortion of important facial structural units and boundaries. http://ift.tt/2t6g2yl

Index

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Note: Page numbers of article titles are in boldface type. http://ift.tt/2sBw5Au

Index

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Note: Page numbers of article titles are in boldface type. http://ift.tt/2sBw5Au

Repair of Auricular Defects

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Repairing defects of the auricle requires an appreciation of the underlying 3-dimensional framework, the flexible properties of the cartilages, and the healing contractile tendencies of the surrounding soft tissue. In the analysis of auricular defects and planning of their reconstruction, it is helpful to divide the auricle into subunits for which different techniques may offer better functional and aesthetic outcomes. This article reviews many of the reconstructive options for defects of the various auricular subunits. http://ift.tt/2t6f3OD

Repair of Auricular Defects

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Repairing defects of the auricle requires an appreciation of the underlying 3-dimensional framework, the flexible properties of the cartilages, and the healing contractile tendencies of the surrounding soft tissue. In the analysis of auricular defects and planning of their reconstruction, it is helpful to divide the auricle into subunits for which different techniques may offer better functional and aesthetic outcomes. This article reviews many of the reconstructive options for defects of the various auricular subunits. http://ift.tt/2t6f3OD

Facial Reconstruction Post-Mohs Surgery

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA http://ift.tt/2sBkQZ0

Facial Reconstruction Post-Mohs Surgery

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA http://ift.tt/2sBkQZ0

Reconstruction of Mohs Defects of the Lips and Chin

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Reconstruction of defects of the lips after Mohs micrographic surgery should encompass functional and aesthetic concerns. The lower lip and chin compose two-thirds of the lower portion of the face. The focus of this article is local tissue transfer for primarily cutaneous defects after Mohs surgery. Various flaps exist for repair. For small defects, elliptical excision with primary closure is a viable option. During reconstruction of the lip, all of the involved layers need to be addressed, including mucosa, muscle, and the vermillion or cutaneous lip. It is especially important to… περισσότερα »

Reconstruction of Mohs Defects of the Lips and Chin

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Reconstruction of defects of the lips after Mohs micrographic surgery should encompass functional and aesthetic concerns. The lower lip and chin compose two-thirds of the lower portion of the face. The focus of this article is local tissue transfer for primarily cutaneous defects after Mohs surgery. Various flaps exist for repair. For small defects, elliptical excision with primary closure is a viable option. During reconstruction of the lip, all of the involved layers need to be addressed, including mucosa, muscle, and the vermillion or cutaneous lip. It is especially important to… περισσότερα »

Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases…περισσότερα »

Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases…περισσότερα »

Copyright

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
ELSEVIER http://ift.tt/2t6g2hP

Copyright

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
ELSEVIER http://ift.tt/2t6g2hP

In Pursuit of Perfection: The Art of Facial Restoration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
One of the common traits that inspire young surgeons to pursue a calling in the reconstructive arts is a passion for restoration. The ability to restore balance and harmony to the human form, to re-create function and beauty in an area where it has been lost or compromised, is one of the requisite fundamental skills that all plastic surgeons seek to acquire and perfect throughout their career. It is the sine qua non in the art of aesthetic and reconstructive surgery. http://ift.tt/2sByE5x

In Pursuit of Perfection: The Art of Facial Restoration

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 12 ώρες
One of the common traits that inspire young surgeons to pursue a calling in the reconstructive arts is a passion for restoration. The ability to restore balance and harmony to the human form, to re-create function and beauty in an area where it has been lost or compromised, is one of the requisite fundamental skills that all plastic surgeons seek to acquire and perfect throughout their career. It is the sine qua non in the art of aesthetic and reconstructive surgery. http://ift.tt/2sByE5x

Contributors

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
J. REGAN THOMAS, MD, FACS http://ift.tt/2t656QX

Contents

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
James B. Lucas http://ift.tt/2sBrYob

Skin and Composite Grafting Techniques in Facial Reconstruction for Skin Cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Skin and composite grafting provide effective resurfacing and reconstruction for cutaneous defects after excision of the malignancy. The goal is to restore a natural appearance and function while preventing distortion of the eyelid, nose, or lips. With careful planning and attention to aesthetic subunits, the surgeon can camouflage incisions and avoid blunting aesthetically sensitive sulci. The surgical plan is also informed by the pathology, as basal or squamous cell carcinomas removed by Mohs micrographic excision have different prognostic and logistical considerations from mela…περισσότερα »

Defect of the Eyelids

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Eyelid defects disrupt the complex natural form and function of the eyelids and present a surgical challenge. Detailed knowledge of eyelid anatomy is essential in evaluating a defect and composing a reconstructive plan. Numerous reconstructive techniques have been described, including primary closure, grafting, and a variety of local flaps. This article describes an updated reconstructive ladder for eyelid defects that can be used in various permutations to solve most eyelid defects. http://ift.tt/2sBuCuc

Flap Basics III

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Paramedian forehead and melolabial flaps are the most common examples of interpolated flaps used by facial plastic surgeons and are excellent options for reconstruction of the midface after Mohs surgery. They provide superior tissue match in terms of thickness, texture, and color, while leaving minimal defects at the tissue donor sites. The main advantage of interpolated flaps is the robust blood supply, which can be either axial of randomly based, and the maintenance of the integrity of facial landmarks. The main disadvantage is the frequent need for a multistage procedure, which…περισσότερα »

Forthcoming Issues

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Trauma in Facial Plastic Surgery http://ift.tt/2sBt1Vb

Flap Basics II

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
A mastery of advancement flap design, selection, and execution greatly aids the surgeon in solving reconstructive dilemmas. Advancement flaps involve carefully planned incisions to most efficiently close a primary defect in a linear vector. Advancement flaps are subcategorized as unipedicle, bipedicle, V-to-Y, and Y-to-V flaps, each with their own advantages and disadvantages. When selecting and designing an advancement flap, the surgeon must account for primary and secondary movement to prevent distortion of important facial structural units and boundaries. http://ift.tt/2t6g2yl

Index

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Note: Page numbers of article titles are in boldface type. http://ift.tt/2sBw5Au

Repair of Auricular Defects

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Repairing defects of the auricle requires an appreciation of the underlying 3-dimensional framework, the flexible properties of the cartilages, and the healing contractile tendencies of the surrounding soft tissue. In the analysis of auricular defects and planning of their reconstruction, it is helpful to divide the auricle into subunits for which different techniques may offer better functional and aesthetic outcomes. This article reviews many of the reconstructive options for defects of the various auricular subunits. http://ift.tt/2t6f3OD

Facial Reconstruction Post-Mohs Surgery

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA http://ift.tt/2sBkQZ0

Reconstruction of Mohs Defects of the Lips and Chin

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Reconstruction of defects of the lips after Mohs micrographic surgery should encompass functional and aesthetic concerns. The lower lip and chin compose two-thirds of the lower portion of the face. The focus of this article is local tissue transfer for primarily cutaneous defects after Mohs surgery. Various flaps exist for repair. For small defects, elliptical excision with primary closure is a viable option. During reconstruction of the lip, all of the involved layers need to be addressed, including mucosa, muscle, and the vermillion or cutaneous lip. It is especially important to… περισσότερα »

Reconstruction of Cheek Defects Secondary to Mohs Microsurgery or Wide Local Excision

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
Successful reconstruction of the cheek following excision for cutaneous malignancy requires careful consideration of defect location, size, and depth in relation to the anatomic properties of the affected cheek unit. Various reconstructive options are available to the surgeon, ranging from simple excisions to complex cervicofacial advancements to meet the needs for functional and aesthetically pleasing reconstructive outcomes. The surgeon must prevent distortion of mobile structures, such as the eyelid, nose, and lips; respect aesthetic subunits; and avoid blunting natural creases…περισσότερα »

Copyright

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
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In Pursuit of Perfection: The Art of Facial Restoration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 12 ώρες
One of the common traits that inspire young surgeons to pursue a calling in the reconstructive arts is a passion for restoration. The ability to restore balance and harmony to the human form, to re-create function and beauty in an area where it has been lost or compromised, is one of the requisite fundamental skills that all plastic surgeons seek to acquire and perfect throughout their career. It is the sine qua non in the art of aesthetic and reconstructive surgery. http://ift.tt/2sByE5x

Personality predicts the vibrancy of colour imagery: The case of synaesthesia

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 15 ώρες
[image: S00109452.gif] Publication date: Available online 1 July 2017 *Source:*Cortex Author(s): Shyla R. Hossain, Julia Simner, Alberta Ipser In this study we show that personality traits predict the physical qualities of mentally generated colours, using the case of synaesthesia. Developmental grapheme-colour synaesthetes have the automatic lifelong association of colours paired to letters or digits. Although these colours are internal mental constructs, they can be measured along physical dimensions such as saturation and luminance. The personality of synaesthetes can also be qua…περισσότερα »

Emergency Department Flow Measures for Adult and Pediatric Patients in British Columbia and Ontario: A Retrospective, Repeated Cross-Sectional Study

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 15 ώρες
[image: S07364679.gif] Publication date: Available online 1 July 2017 *Source:*The Journal of Emergency Medicine Author(s): Gregory Georgio, Astrid Guttmann, Quynh H. Doan BackgroundEvidence suggests emergency department (ED) overcrowding is associated with poor health outcomes. Children comprise 20–25% of general ED visits, yet few studies have examined the differential impact of ED overcrowding on pediatric and adult populations.ObjectiveThe primary objective of this study was to compare flow measures, such as wait time to see a physician, length of stay (LOS), and rate of patients… περισσότερα »

Autophagy inhibition enabled efficient photothermal therapy at a mild temperature

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 16 ώρες
[image: S01429612.gif] Publication date: October 2017 *Source:*Biomaterials, Volume 141 Author(s): Zhengjie Zhou, Yang Yan, Kewen Hu, Yuan Zou, Yiwen Li, Rui Ma, Qiang Zhang, Yiyun Cheng The heterogeneously-distributed hyperthermia in nanomaterial-mediated photothermal therapy commonly results in incomplete tumor eradication and serious damage of health tissue. Here, we found autophagy was activated in cancer cells underwent photothermal therapy and the inhibition of autophagy significantly enhanced the efficacy of photothermal killing of cancer cells. A formulation of chloroquine-l… περισσότερα »

Editorial board

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 16 ώρες
[image: alertIcon.gif] Publication date: September 2017 *Source:*Biomaterials, Volume 140 http://ift.tt/2suTKr8

Macrophages with cellular backpacks for targeted drug delivery to the brain

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 16 ώρες
[image: 1-s2.0-S0142961217X00215-cov150h.gif] Publication date: September 2017 *Source:*Biomaterials, Volume 140 Author(s): Natalia L. Klyachko, Roberta Polak, Matthew J. Haney, Yuling Zhao, Reginaldo J. Gomes Neto, Michael C. Hill, Alexander V. Kabanov, Robert E. Cohen, Michael F. Rubner, Elena V. Batrakova Most potent therapeutics are unable to cross the blood-brain barrier following systemic administration, which necessitates the development of unconventional, clinically applicable drug delivery systems. With the given challenges, biologically active vehicles are crucial to accomp… περισσότερα »

Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 17 ώρες
[image: S10811206.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma &amp; Immunology Author(s): Robert D. Pesek, Mallikarjuna Rettiganti, Erin O'Brien, Sarah Beckwith, Caroline Daniel, Chunqiao Luo, Amy M. Scurlock, Peggy Chandler, Rebecca A. Levy, Tamara T. Perry, Joshua L. Kennedy, Sheva Chervinskiy, Maryelle Vonlanthen, Helen Casteel, Stephen C. Fiedorek, Troy Gibbons, Stacie M. Jones BackgroundIn children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits.Objecti… περισσότερα »

Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 17 ώρες
[image: S10811206.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma &amp; Immunology Author(s): Robert D. Pesek, Mallikarjuna Rettiganti, Erin O'Brien, Sarah Beckwith, Caroline Daniel, Chunqiao Luo, Amy M. Scurlock, Peggy Chandler, Rebecca A. Levy, Tamara T. Perry, Joshua L. Kennedy, Sheva Chervinskiy, Maryelle Vonlanthen, Helen Casteel, Stephen C. Fiedorek, Troy Gibbons, Stacie M. Jones BackgroundIn children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits.Objecti… περισσότερα »

Epinephrine use for anaphylaxis: Too seldom, too late

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 17 ώρες
[image: alertIcon.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma &amp; Immunology Author(s): Rishma Chooniedass, Beverley Temple, Allan Becker http://ift.tt/2tEDCUi

Epinephrine use for anaphylaxis: Too seldom, too late

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 17 ώρες
[image: alertIcon.gif] Publication date: Available online 1 July 2017 *Source:*Annals of Allergy, Asthma &amp; Immunology Author(s): Rishma Chooniedass, Beverley Temple, Allan Becker http://ift.tt/2tEDCUi

Corrigendum to “Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist”

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 17 ώρες
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Corrigendum to “Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist”

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 17 ώρες
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Corrigendum to “Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist”

Alexandros SfakianakisστοCancer by Sfakianakis AlexandrosΠριν από 17 ώρες
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Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 17 ώρες
Publication date: Available online 1 July 2017 *Source:*Allergology International Author(s): Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima BackgroundWe have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice.MethodsBALB/c mice were sensi… περισσότερα »

Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 17 ώρες
Publication date: Available online 1 July 2017 *Source:*Allergology International Author(s): Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima BackgroundWe have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice.MethodsBALB/c mice were sensi… περισσότερα »

Prodrugs in medicinal chemistry and enzyme prodrug therapies

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 17 ώρες
Publication date: Available online 1 July 2017 *Source:*Advanced Drug Delivery Reviews Author(s): Raoul Walther, Jarkko Rautio, Alexander N. Zelikin Prodrugs are cunning derivatives of therapeutic agents designed to improve the pharmacokinetics profile of the drug. Within a prodrug, pharmacological activity of the drug is masked and is recovered within the human body upon bioconversion of the prodrug, a process that is typically mediated by enzymes. This concept is highly successful and a significant fraction of marketed therapeutic formulations is based on prodrugs. An advanced subs… περισσότερα »

Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein expression predicts disease severity in chronic hepatitis C patients

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 18 ώρες
Publication date: Available online 1 July 2017 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Ching-I Huang, Chung-Feng Huang, Ming-Lun Yeh, Yi-Hung Lin, Po-Cheng Liang, Meng-Hsuan Hsieh, Chia-Yen Dai, Ming-Yen Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) has recently been developed as a promising liver fibrosis glyco biomarker. We assessed its efficacy in evaluating liver disease severity in chronic hepatitis C (CHC) in Taiwan. The association between WFA+-M2… περισσότερα »

Acceleration of skin wound healing by low-dose indirect ionizing radiation in male rats

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 18 ώρες
Publication date: Available online 1 July 2017 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Nasrollah Jabbari, Gholam Hossein Farjah, Behnam Ghadimi, Hajar Zanjani, Behnam Heshmatian A recent hypothesis has revealed that low-dose irradiation (LDI) with ionizing radiation might have a promoting effect on fracture healing. The aim of this study was to investigate the influence of direct (electron beam) and indirect (gamma-ray) low-dose ionizing irradiations on the wound healing process in male rats. In 72 male rats, a full-thickness wound was incised. The animals were… περισσότερα »

High frequencies of a favorable IL-28B rs8099917 polymorphism and the clinical implications in patients with HCV in one multiracial area of Taiwan

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 18 ώρες
Publication date: Available online 1 July 2017 *Source:*The Kaohsiung Journal of Medical Sciences Author(s): Chun-Han Cheng, Ching-Chung Lin, Huan-Lin Chen, I.-Tsung Lin, Chia-Hsien Wu, Yuan-Kai Lee, Ming-Wun Wong, Ming-Jong Bair There is a strong association between hepatitis C virus (HCV) treatment efficacy and the interleukin (IL)-28B gene. However, the IL-28B variant’s distribution and potential role in the therapeutic response are not well established in Taitung, a racially diverse county in Taiwan. Here, we investigated the distribution pattern of IL-28B rs8099917 and its influ…περισσότερα »

Evaluation of Sedation-Related Medication Errors in Contact Isolation Patients in the ICU.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 19 ώρες
*Evaluation of Sedation-Related Medication Errors in Contact Isolation Patients in the ICU.* J Hosp Infect. 2017 Jun 27;: Authors: Searcy R, Johnson D, Jankowski C, Ferreira J Abstract BACKGROUND: Patients in the intensive care unit (ICU), may be placed in contact isolation (CI) for meticillin-resistant Staphylococcus aureus (MRSA) colonization to prevent transmission. Prior studies suggest that isolated patients may receive substandard care compared to patients not on isolation. An optimal level of sedation is required to facilitate mechanical ventilation (MV) and to minimize ad… περισσότερα »

Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 19 ώρες
*Synthesis and biological evaluation of novel steroidal 5α,8α-epidioxyandrost-6-ene-3β-ol-17-(O-phenylacetamide)oxime derivatives as potential anticancer agents.* Bioorg Med Chem Lett. 2017 Jun 21;: Authors: Bu M, Cao T, Li H, Guo M, Yang BB, Zeng C, Zhou Y, Zhang N, Hu L Abstract Inspired by the significant anti-cancer activity of our previously screened natural ergosterol peroxide (EP, 1), we synthesized and characterized a series of novel 5α,8α-epidioxyandrost-3β-ol-17-(O-phenylacetamide)oxime derivatives (9a-o). The anti-proliferative activity of the synthesized compounds aga… περισσότερα »

Staged definitive repair after carotid blowout: a case report.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 19 ώρες
*Staged definitive repair after carotid blowout: a case report.* Ann Vasc Surg. 2017 Jun 27;: Authors: Loja MN, Abbot C, Isaacs R, Brawley J, Humphries M Abstract Carotid blowout syndrome is a highly morbid complication of head and neck cancer. We present the case of a 51-year old woman with common carotid artery blowout, initially temporized with an endovascular stent graft and ultimately reconstructed using autologous superficial femoral artery. The patient recovered without sequelae and continues to be asymptomatic at one year. We present the modern hybrid management of this co… περισσότερα »

Joint Attention and Oromotor Abilities in Young Children With and Without Autism Spectrum Disorder

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 20 ώρες
[image: S00219924.gif] Publication date: Available online 1 July 2017 *Source:*Journal of Communication Disorders Author(s): Jennifer C. Dalton, Elizabeth R. Crais, Shelley L. Velleman PurposeThis study examined the relationship between joint attention ability and oromotor imitation skill in three groups of young children with and without Autism Spectrum Disorder using both nonverbal oral and verbal motor imitation tasks. Research questions addressed a) differences among joint attention and oromotor imitation abilities; b) the relationship between independently measured joint attenti… περισσότερα »

Inferior Limb Salvage by Combined Free-tissue Transfer and the Crane Principle Revisited

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 20 ώρες
[image: image]Summary: Aggressive treatment of ischemia of the lower extremities has decreased the number of amputations in both diabetic and nondiabetic patients; combined vascular reconstruction and microvascular free-flap transfer has been used to improve distal perfusion and cover large tissue defects caused by the critical limb ischemia during the past 30 years. We present our experience with a 71-year-old diabetic patient who underwent revascularization with a vascular bypass and a simultaneous microvascular flap reconstruction for limb salvage after domestic trauma. An extens… περισσότερα »

Geospatial analysis of dissolved nutrients dataset in the surface water of Karayar reservoir, Southern India

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 20 ώρες
Publication date: August 2017 *Source:*Data in Brief, Volume 13 Author(s): N.S. Magesh, N. Chandrasekar, S. Krishnakumar Spatial dataset representing the nutrient distribution in Karayar reservoir during pre and post-monsoon season is presented. Random sampling method was used for data collection and the sample location were fixed using a handheld global positioning system (Garmin GPSMAP-76). The nutrients were estimated using the standard techniques as described in the American Public Health Association (APHA) manual. Physical parameters were estimated using a Hanna portable multi … περισσότερα »

Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 20 ώρες
Sertoli-Leydig Cell Tumors (SLCTs) make up http://ift.tt/2tzC4tY

Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature

Alexandros SfakianakisστοCancer by Sfakianakis AlexandrosΠριν από 20 ώρες
Sertoli-Leydig Cell Tumors (SLCTs) make up http://ift.tt/2tzC4tY

Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 20 ώρες
Sertoli-Leydig Cell Tumors (SLCTs) make up http://ift.tt/2tzC4tY

Shaping functional gut microbiota using dietary bioactives to reduce colon cancer risk

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
[image: S1044579X.gif] Publication date: Available online 1 July 2017 *Source:*Seminars in Cancer Biology Author(s): Derek V. Seidel, M. Andrea Azcárate-Peril, Robert S. Chapkin, Nancy D. Turner Colon cancer is a multifactorial disease associated with a variety of lifestyle factors. Alterations in the gut microbiota and the intestinal metabolome are noted during colon carcinogenesis, implicating them as critical contributors or results of the disease process. Diet is a known determinant of health, and as a modifier of the gut microbiota and its metabolism, a critical element in main… περισσότερα »

Nutrigenomics in cancer: revisiting the effects of natural compounds

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
[image: S1044579X.gif] Publication date: Available online 1 July 2017 *Source:*Seminars in Cancer Biology Author(s): Cornelia Braicu, Nikolay Mehterov, Boyan Vladimirov, Victoria Sarafian, Seyed Nabavi, Atanas G. Atanasov, Ioana Berindan-Neagoe Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment. The impact of dietary components, including phytochemicals, is largely studied by nutrigenomics, looking at the gene expression and molecular mechanisms interacting with bioactive compounds a… περισσότερα »

Transition from melting to carbonization of naphthalene, anthracene, pyrene and coronene at high pressure

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
Publication date: Available online 1 July 2017 *Source:*Physics of the Earth and Planetary Interiors Author(s): Artem D. Chanyshev, Konstantin D. Litasov, Anton F. Shatskiy, Igor S. Sharygin, Yuji Higo, Eiji Ohtani We have examined the decomposition of naphthalene, anthracene, pyrene and coronene at high pressures and temperatures. Experiments were performed using in situ X-ray diffraction in multianvil apparatus at the SPring-8 synchrotron radiation facility. In the pressure range of 1.5–3.7 GPa decomposition of studied polycyclic aromatic hydrocarbons (PAHs) was detected at 773–97…περισσότερα »

Therapeutic application of human leukocyte antigen-G1 improves atopic dermatitis-like skin lesions in mice

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
Publication date: September 2017 *Source:*International Immunopharmacology, Volume 50 Author(s): Naoyoshi Maeda, Chisato Yamada, Ami Takahashi, Kimiko Kuroki, Katsumi Maenaka Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that plays critical roles in immune response and in triggering inhibitory signaling to immune cells such as T cells, natural killer cells, and antigen-presenting cells. Thus, the application of HLA-G can be considered for treating immune response-related inflammatory disorders. We have previously reported that treatment with HLA-G1 and HLA-G2 amel… περισσότερα »

Investigation of the biodistribution, breakdown and excretion of delta inulin adjuvant

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
[image: S0264410X.gif] Publication date: Available online 1 July 2017 *Source:*Vaccine Author(s): Lixin Wang, Thomas Barclay, Yunmei Song, Paul Joyce, Isaac G. Sakala, Nikolai Petrovsky, Sanjay Garg Insoluble, nanostructured delta inulin particles enhance the immunogenicity of co-administered protein antigens and consequently are used as a vaccine adjuvant (Advax™). To better understand their immunomodulatory properties, the in vitro hydrolysis and in vivo distribution of delta inulin particles were investigated. Delta inulin particle hydrolysis under bio-relevant acidic conditions …περισσότερα »

New perspectives for hexavalent vaccines

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
[image: S0264410X.gif] Publication date: Available online 1 July 2017 *Source:*Vaccine Author(s): Pablo Obando-Pacheco, Irene Rivero-Calle, José Gómez-Rial, Carmen Rodríguez-Tenreiro Sánchez, Federico Martinón-Torres With the increase in the number of routine vaccinations the development of pentavalent and hexavalent combination vaccines fitting the routine vaccination schedules became a necessity. In this respect, Europe has taken the lead in comparison with other world regions, and routine vaccination with pentavalent and hexavalent combinations including DTPa, Hib, HepB and IPV h… περισσότερα »

Knowledge of influenza vaccination recommendation and early vaccination uptake during the 2015–16 season among adults aged ≥18years – United States

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
[image: S0264410X.gif] Publication date: Available online 1 July 2017 *Source:*Vaccine Author(s): Peng-jun Lu, Anup Srivastav, Tammy A. Santibanez, M. Christopher Stringer, Michael Bostwick, Jill A. Dever, Marshica Stanley Kurtz, Walter W. Williams BackgroundSince 2010, the Advisory Committee on Immunization Practices (ACIP) has recommended that all persons aged ≥6months receive annual influenza vaccination.MethodsWe analyzed data from the 2015 National Internet Flu Survey (NIFS), to assess knowledge and awareness of the influenza vaccination recommendation and early influenza vacci… περισσότερα »

Inferior Limb Salvage by Combined Free-tissue Transfer and the Crane Principle Revisited

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
[image: image]Summary: Aggressive treatment of ischemia of the lower extremities has decreased the number of amputations in both diabetic and nondiabetic patients; combined vascular reconstruction and microvascular free-flap transfer has been used to improve distal perfusion and cover large tissue defects caused by the critical limb ischemia during the past 30 years. We present our experience with a 71-year-old diabetic patient who underwent revascularization with a vascular bypass and a simultaneous microvascular flap reconstruction for limb salvage after domestic trauma. An extens… περισσότερα »

iTRAQ-based quantitative proteomic analysis reveals multiple effects of Emodin to Haemophilus parasuis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 21 ώρες
Publication date: Available online 2 July 2017 *Source:*Journal of Proteomics Author(s): Li Li, Ye Tian, Jiankang Yu, Xu Song, Renyong Jia, Qiankun Cui, Wenzhi Tong, Yuanfeng Zou, Lixia Li, Lizi Yin, Xiaoxia Liang, Changliang He, Guizhou Yue, Gang Ye, Ling Zhao, Fei Shi, Cheng Lv, Sanjie Cao, Zhongqiong Yin Haemophilus parasuis, a symbiotic bacteria of upper respiratory tract of swine, is the etiological agent of Glässer’s disease, which is characterized by fibrinous polyserositis. Emodin, exhibits antibacterial activity against H. parasuis, yet the action mode has not been fully u…περισσότερα »

Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
*Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Trimarchi M, Bondi S, Della Torre E, Terreni MR, Bussi M Abstract Cocaine abuse occasionally causes extensive destruction of the osteocartilaginous structures of the nose, sinuses and palate, which mimics the clinical picture of other diseases associated with necrotising midfacial lesions. The differentiation of cocaine-induced midline destructive lesions (CIMDL) and limited granulomatosis with polyangiitis (GPA)…περισσότερα »

Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
*Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Trimarchi M, Bondi S, Della Torre E, Terreni MR, Bussi M Abstract Cocaine abuse occasionally causes extensive destruction of the osteocartilaginous structures of the nose, sinuses and palate, which mimics the clinical picture of other diseases associated with necrotising midfacial lesions. The differentiation of cocaine-induced midline destructive lesions (CIMDL) and limited granulomatosis with polyangiitis (GPA)…περισσότερα »

Cost-effectiveness strategies in OSAS management: a short review.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
*Cost-effectiveness strategies in OSAS management: a short review.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Toraldo DM, Passali D, Sanna A, De Nuccio F, Conte L, De Benedetto M Abstract Obstructive sleep apnoea (OSAS) is an underdiagnosed chronic disease with a high prevalence in adults. It is becoming a significant social problem, since it is associated with a worsening in quality of life and increase in mortality. The cost-effectiveness ratio of diagnostic and therapeutic management of OSAS is a strategic issue to counteract the expected increasing demand of objectiv… περισσότερα »

Cost-effectiveness strategies in OSAS management: a short review.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
*Cost-effectiveness strategies in OSAS management: a short review.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Toraldo DM, Passali D, Sanna A, De Nuccio F, Conte L, De Benedetto M Abstract Obstructive sleep apnoea (OSAS) is an underdiagnosed chronic disease with a high prevalence in adults. It is becoming a significant social problem, since it is associated with a worsening in quality of life and increase in mortality. The cost-effectiveness ratio of diagnostic and therapeutic management of OSAS is a strategic issue to counteract the expected increasing demand of objectiv… περισσότερα »

Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
*Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Cadoni G, Giraldi L, Petrelli L, Pandolfini M, Giuliani M, Paludetti G, Pastorino R, Leoncini E, Arzani D, Almadori G, Boccia S Abstract This study was undertaken to evaluate the association between demographics, lifestyle habits, and clinical data and overall survival (OS), recurrence and second primary cancer (SPC) in patients with first primary head and neck cancer (HNC). We retrospectively reviewed data from 482 pat…περισσότερα »

Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
*Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.* Acta Otorhinolaryngol Ital. 2017 Jun 30;: Authors: Cadoni G, Giraldi L, Petrelli L, Pandolfini M, Giuliani M, Paludetti G, Pastorino R, Leoncini E, Arzani D, Almadori G, Boccia S Abstract This study was undertaken to evaluate the association between demographics, lifestyle habits, and clinical data and overall survival (OS), recurrence and second primary cancer (SPC) in patients with first primary head and neck cancer (HNC). We retrospectively reviewed data from 482 pat…περισσότερα »

Loss of Tyrosine Kinase 2 Does Not Affect the Severity of Jak2V617F-induced Murine Myeloproliferative Neoplasm

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: In myeloproliferative neoplasms (MPN), Janus kinase 2 (JAK2) is activated by mutations including JAK2V617F (JAK2VF). It is unclear whether JAK kinases [i.e. JAK1, JAK2, JAK3, or tyrosine kinase 2 (TYK2)] other than JAK2 have cooperative actions such as enhancement or suppression of JAK2. If other kinases enhance activation, therapies that co-target them could have a therapeutic efficacy. We examined the role of TYK2 in Jak2VF-induced murine MPN. Materials and Methods: We crossed Jak2VF transgenic mice and Tyk2-knockout (Tyk2KO) mice to generate Jak2VF/Tyk2KO mice. … περισσότερα »

Evaluation of a New Technique for iFOBT Utilising a New Sample Collection Device with Increased Buffer Stability

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Aims: The aims of the present study were: (i) Evaluate specificity and sensitivity of Hb Smart enzyme-linked immunosorbent assay (ELISA) (ScheBo Biotech) compared to colonoscopy results and (ii) assess stability of a new sample collection device containing a newly formulated buffer to extract haemoglobin using buffer and stool samples spiked with defined concentrations of haemoglobin. Materials and Methods: Stool samples were quantified with the ELISA method. The stability of haemoglobin in the extraction buffer and in native stool samples, respectively, was determined daily by EL… περισσότερα »

Desmoid Tumors in Familial Adenomatous Polyposis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Familial adenomatous polyposis (FAP) is a cancer syndrome caused by a germline mutation in the adenomatous polyposis coli (APC) gene. It is characterized by the presence of hundreds of colonic polyps, which have a high tendency to undergo malignant transformation. Among associated lesions in FAP, desmoid tumors represent a common possible life-threatening condition that requires special attention. They are rare tumors occurring with a particularly high incidence in FAP, especially after surgery. In agreement with Knudson’s ‘two-hit’ theory, the inactivation of the residual APC gen…περισσότερα »

Serum Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) as a Biomarker for Primary Ovarian Cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational therapeutic target for ovarian cancer. Here, we evaluated the clinical significance of serum HB-EGF by examining the association between prognosis and serum HB-EGF levels in patients with primary ovarian cancer. We found that high serum HB-EGF concentrations were signifi… περισσότερα »

Application of Cancer Cell Reprogramming Technology to Human Cancer Research

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
The cancer stem cell (CSC) hypothesis is an evolving concept of oncogenesis that has recently gained wide acceptance. By definition, CSCs exhibit continuous proliferation and self-renewal, and they have been proposed to play significant roles in oncogenesis, tumor growth, metastasis, chemoresistance, and cancer recurrence. The reprogramming of cancer cells using induced pluripotent stem cell (iPSC) technology is a potential strategy for the identification of CSC-related oncogenes and tumor-suppressor genes. This technology has some advantages for studying the interactions between … περισσότερα »

Hepatitis B Reactivation in a Patient Receiving Chemotherapy for Breast Cancer: A Case Report

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Hepatitis B virus (HBV) reactivation is a known complication of immunosuppressive therapy. While patients who are undergoing treatment with anti-CD20 agents or stem cell transplantation are commonly screened for chronic HBV infection prior to treatment, there are no consensus guidelines regarding HBV screening for patients undergoing chemotherapy for solid tumors. We present a rare case of fulminant liver failure due to HBV reactivation in a patient receiving chemotherapy for breast cancer. Our case highlights the importance of developing definitive guidelines regarding HBV screen… περισσότερα »

Clinical Implications of Augmenter of Liver Regeneration in Cancer: A Systematic Review

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: Hepatocellular carcinoma is a substantial healthcare burden with high prevalence and poor prognosis. As such, efforts are continually made to uncover molecules relevant in cancer biology, that are exploitable as targets for therapy. The mitochondrion is the powerhouse of the cell and exhibits altered functionality in the malignant state, including aberrant regulation of apoptosis and cellular respiration. Augmenter of liver regeneration (ALR) is a multifunctional mitochondrial protein that demonstrates anti-oxidative and anti-apoptotic properties and plays a key ro…περισσότερα »

Measurement of the Phagocytic Activity of Human Peripheral Blood Using a Highly Sensitive Fluorometric Detection Device Without Hemolysis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: Phagocytes recognize pathogens that enter the body as well as other abnormal and foreign materials that may exist within an organism (such as dead cells, oxidized lipids, and denatured proteins), and phagocytose and eliminate them to maintain a healthy state. In a previous study a simple prototype device was used, under development by Hamamatsu Photonics (Prototype), that detects fluorescence to determine the phagocytic activity of the murine macrophage cell line J774.1. The present study aimed to determine whether it was possible to detect phagocytic activity in a… περισσότερα »

Inhibition of ERG Activity in Patient-derived Prostate Cancer Xenografts by YK-4-279

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: The aim of the current study was to determine the effects of the ERG small-molecule inhibitor YK-4-279 on ERG+ prostate cancer patient-derived xenografts (PDX). Materials and Methods: ERG activity was blocked using YK-4-279 in three subcutaneously-implanted ERG+ (LuCaP 23.1, 86.2 and 35) and one ERG– (LuCaP 96) PDX. Treated animals tumor volume (TV), body weight (BW) and serum prostate-specific antigen (PSA) were compared to vehicle-treated control animals. Gene expression, proliferation, apoptosis, microvessel density and ERG expression were also assessed. Results… περισσότερα »

Axitinib for Gemcitabine-refractory Advanced Biliary Tract Cancer: Report of 5 Cases

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: Vascular endothelial growth factor receptor (VEGFR) has been identified as a treatment target for biliary tract cancer (BTC) and axitinib is a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-1/2/3. This study was conducted as a preliminary evaluation of the safety and efficacy of axitinib for patients with advanced BTC. Patients and Methods: Patients refractory to gemcitabine-based regimens were administered axitinib at the dose of 5 mg twice daily. Results: Five patients (3 male and 2 female) with a median age of 68 years were enrolled. … περισσότερα »

A Novel mTOR Inhibitor; Anthracimycin for the Treatment of Human Hepatocellular Carcinoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: Anthracimycin, a secondary metabolite of Streptomyces, has been shown to inhibit the invasion of certain cancer cell lines. Materials and Methods: In this study we evaluated the effect of anthracimycin on cell growth and signaling pathways in hepatocellular carcinoma (HCC). Results: Anthracimycin suppressed cell proliferation and motility and induced apoptosis in human HCC cell lines. Furthermore, anthracimycin had no effect on the enrichment of EpCAM-high liver cancer stem cells (CSCs), while fluorouracil dramatically enriched the CSCs with activation of the stemn…περισσότερα »

Impact and Prediction of Lymph Node Involvement in Patients with Intrahepatic Cholangiocarcinoma After Curative Resection

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factors. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R&gt;0) independently predicted long-term OS in the wh… περισσότερα »

Patient-derived Xenografts from Colorectal Carcinoma: A Temporal and Hierarchical Study of Murine Stromal Cell Replacement

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: Patient-derived xenografting (PDX) of human colorectal cancer (CRC) is the preferred experimental model to study tumor response to therapeutic agents. Gradually, human stromal cells are replaced by mouse stromal cells; however, the exact timing of the replacement of human with murine stromal cells in human CRC xenograft has not been fully elucidated. We hypothesize that orthologous murine transcripts functionally substitutes for the loss due to replacement of human stromal genes. Materials and Methods: Human CRC were implanted in athymic nude mice in replicates and … περισσότερα »

Factors Influencing Disease Progression in Patients with Head and Neck Melanoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background: Histological parameters as well as the status of sentinel lymph node are known to be strong prognostic factors in patients with melanoma. Patients and Methods: In this study, we retrospectively analyzed 1,384 patients who were diagnosed with head and neck melanoma between 1976 and 2010 regarding prognostic factors [tumor thickness, level of invasion, sentinel lymph node (SLN) status, ulceration, histological subtype, localization, and gender], overall survival, and disease-free survival. Results: Patients who developed metastases had a significantly thicker tumor than … περισσότερα »

Effect of Lonidamine on Systemic Therapy of DB-1 Human Melanoma Xenografts with Temozolomide

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: Since temozolomide (TMZ) is activated under alkaline conditions, we expected lonidamine (LND) to have no effect or perhaps diminish its activity, but initial results suggest it may actually enhance either or both short- and long-term activity of TMZ in melanoma xenografts. Materials and Methods: Cohorts of 5 mice with subcutaneous xenografts ~5 mm in diameter were treated with saline (control (CTRL)), LND only, TMZ only or LND followed by TMZ at t=40 min (time required for maximal tumor acidification). Results: Mean tumor volume for LND+TMZ for the period between 6… περισσότερα »

Efficacy of Combination Therapy with MET and VEGF Inhibitors for MET-overexpressing Glioblastoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background: Glioblastoma multiforme (GBM) is a malignant brain tumor with an extremely poor prognosis. GBM tissues frequently express mesenchymal–epithelial transition factor (MET), which induces cell division, growth and migration. In addition, angiogenesis is a significant feature of GBM, attributable to the overexpression of vascular endothelial growth factor (VEGF). Although the VEGF inhibitor bevacizumab was recently highlighted as the second-line drug for GBM treatment, GBMs often recur even with bevacizumab therapy. Based on these findings, we hypothesized that inhibition o… περισσότερα »

Increased Nicotinamide Phosphoribosyltransferase and Cystathionine-{beta}-Synthase in Renal Oncocytomas, Renal Urothelial Carcinoma, and Renal Clear Cell Carcinoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background: Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD+ synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H2S)-synthesizing enzyme levels, including cystathionine-β-synthase (CBS). Materials and Methods: We used tissue microarrays to examine Nampt and the H2S-synthesizing enzyme CBS protein levels in benign kidney, RCC, UC and ROs. Results: Compared to benign kidney, all thre… περισσότερα »

Systemic Intravenous Adoptive Transfer of Autologous Lymphokine-activated {alpha}{beta} T-Cells Improves Temozolomide-induced Lymphopenia in Patients with Glioma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
In this clinical study, we investigated the safety and clinical usefulness of systemic adoptive immunotherapy using autologous lymphokine-activated αβ T-cells (αβ T-cells), combined with standard therapies, in patients with malignant brain tumors. Twenty-three patients with different malignant brain tumors, consisting of 14 treated with temozolomide (TMZ group) and 9 treated without temozolomide (non-TMZ group), received systemic intravenous injections of αβ T-cells (mean=10.4 injections/patient for the TMZ group, and 4.78 for the non-TMZ group). No significant adverse effects asso… περισσότερα »

Choline-Deficient-Diet-Induced Fatty Liver Is a Metastasis-Resistant Microenvironment

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
Background/Aim: Fatty liver disease is increasing in the developed and developing world. Liver metastasis from malignant lymphoma in the fatty liver is poorly understood. In a previous report, we developed color-coded imaging of the tumor microenvironment (TME) of the murine EL4-RFP malignant lymphoma during metastasis, including the lung. In the present report, we investigated the potential and microenvironment of the fatty liver induced by a choline-deficient diet as a metastatic site in this mouse lymphoma model. Materials and Methods: C57BL/6-GFP transgenic mice were fed with a… περισσότερα »

Errata

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 22 ώρες
http://ift.tt/2tdR7Hs

An aspect of the object habit: Pliny the Elder, audience and politics

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Libonati, E; (2017) An aspect of the object habit: Pliny the Elder, audience and politics. Museum History Journal pp. 1-13. 10.1080/19369816.2017.1328791 . http://ift.tt/2t4UZvU

Consensus-based guidelines for Video EEG monitoring in the pre-surgical evaluation of children with epilepsy in the UK.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Pressler, RM; Seri, S; Kane, N; Martland, T; Goyal, S; Iyer, A; Warren, E; Pressler, RM; Seri, S; Kane, N; Martland, T; Goyal, S; Iyer, A; Warren, E; Notghi, L; Bill, P; Thornton, R; Appleton, R; Doyle, S; Rushton, S; Worley, A; Boyd, SG; CESS Clinical Neurophysiology working group, ; – view fewer (2017) Consensus-based guidelines for Video EEG monitoring in the pre-surgical evaluation of children with epilepsy in the UK. Seizure , 50 pp. 6-11. 10.1016/j.seizure.2017.05.008 . http://ift.tt/2sAfMnu

Calling all health professionals for a safer, fairer and better world

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
De C Williams, AC; Orlowska, D; (2014) Calling all health professionals for a safer, fairer and better world. Psychologist , 27 (2) 67-. http://ift.tt/2t5djVS

Invasion of the bloggers: A preliminary study on the demography and content of the economic blogosphere

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Mata, T; (2011) Invasion of the bloggers: A preliminary study on the demography and content of the economic blogosphere. In: The Elgar Companion to Recent Economic Methodology. (pp. 514-524). http://ift.tt/2sAj7D0

Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson’s disease treated with L-DOPA.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Lees, AJ; Ferreira, J; Rascol, O; Reichmann, H; Stocchi, F; Tolosa, E; Poewe, W; (2017) Opicapone for the management of end-of-dose motor fluctuations in patients with Parkinson’s disease treated with L-DOPA. Expert Rev Neurother , 17 (7) pp. 649-659. 10.1080/14737175.2017.1336086 . http://ift.tt/2t4Z2Z1

The relationship between the First World War and neurology: 100 years of "Shell Shock".

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Pedroso, JL; Linden, SC; Barsottini, OG; Maranhão, P; Lees, AJ; (2017) The relationship between the First World War and neurology: 100 years of "Shell Shock". Arq Neuropsiquiatr , 75 (5) pp. 317-319. 10.1590/0004-282X20170046 . http://ift.tt/2sADW1j

Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Xu, Y; Li, J-J; Yu, D-G; Williams, GR; Yang, J-H; Wang, X; (2017) Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior. Eur J Pharm Sci , 106 pp. 422-430. 10.1016/j.ejps.2017.06.017 . http://ift.tt/2t4U7Y9

Finding the grave of Sir William Richard Gowers.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Boes, CJ; Toodayan, N; Lees, A; (2017) Finding the grave of Sir William Richard Gowers. Pract Neurol 10.1136/practneurol-2017-001648 . http://ift.tt/2sAJqZU

Concerns Regarding Opicapone as Adjunct to Levodopa Therapy-Reply.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Lees, AJ; Rocha, J-F; Soares-da-Silva, P; (2017) Concerns Regarding Opicapone as Adjunct to Levodopa Therapy-Reply. JAMA Neurol 10.1001/jamaneurol.2017.0726 . http://ift.tt/2t51pvb

Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
De Pablo-Fernandez, E; Tur, C; Revesz, T; Lees, AJ; Holton, JL; Warner, TT; (2017) Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease. JAMA Neurol 10.1001/jamaneurol.2017.1125 . http://ift.tt/2sAifOH

Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Todd, J; Glynn, JR; Marston, M; Lutalo, T; Biraro, S; Mwita, W; Suriyanon, V; Todd, J; Glynn, JR; Marston, M; Lutalo, T; Biraro, S; Mwita, W; Suriyanon, V; Rangsin, R; Nelson, KE; Sonnenberg, P; Fitzgerald, D; Karita, E; Żaba, B; – view fewer (2007) Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy. AIDS , 21 (Suppl 6) S55-S63. 10.1097/01.aids.0000299411.75269.e8 . http://ift.tt/2t52FOO

Classification of drug-resistant tuberculosis.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Sonnenberg, P; Godfrey-Faussett, P; Glynn, JR; Shearer, S; Murray, J; (2000) Classification of drug-resistant tuberculosis. Lancet , 356 (9245) pp. 1930-1931. 10.1016/S0140-6736(05)73482-6 . http://ift.tt/2sAyTO9

Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Murray, J; Sonnenberg, P; Nelson, G; Bester, A; Shearer, S; Glynn, JR; (2007) Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners. AIDS , 21 (Suppl 6) S97-S104. 10.1097/01.aids.0000299416.61808.24 . http://ift.tt/2t4XFJM

Estimating ‘net’ HIV-related mortality and the importance of background mortality rates

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Marston, M; Todd, J; Glynn, JR; Nelson, KE; Rangsin, R; Lutalo, T; Urassa, M; Marston, M; Todd, J; Glynn, JR; Nelson, KE; Rangsin, R; Lutalo, T; Urassa, M; Biraro, S; Van der Paal, L; Sonnenberg, P; Żaba, B; – view fewer (2007) Estimating ‘net’ HIV-related mortality and the importance of background mortality rates. AIDS , 21 (Suppl 6) S65-S71. 10.1097/01.aids.0000299412.82893.62 . http://ift.tt/2sAbwVc

The Long-term Effects of Early Track Choice

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Dustmann, C; Puhani, PA; Schönberg, U; (2017) The Long-term Effects of Early Track Choice. Economic Journal 10.1111/ecoj.12419 . (In press). http://ift.tt/2t57sQa

Buckling in armored droplets.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Sicard, F; Striolo, A; (2017) Buckling in armored droplets. Nanoscale , 9 (25) pp. 8567-8572. 10.1039/c7nr01911d . http://ift.tt/2sAidGz

Water Oxidation Kinetics of Accumulated Holes on the Surface of a TiO 2 Photoanode: A Rate Law Analysis

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Kafizas, A; Ma, Y; Pastor, E; Pendlebury, SR; Mesa, C; Francàs, L; Le Formal, F; Kafizas, A; Ma, Y; Pastor, E; Pendlebury, SR; Mesa, C; Francàs, L; Le Formal, F; Noor, N; Ling, M; Sotelo-Vazquez, C; Carmalt, CJ; Parkin, IP; Durrant, JR; – view fewer (2017) Water Oxidation Kinetics of Accumulated Holes on the Surface of a TiO 2 Photoanode: A Rate Law Analysis. ACS Catalysis pp. 4896-4903. 10.1021/acscatal.7b01150 . http://ift.tt/2t4ZUwZ

Late recovery of awareness in prolonged disorders of consciousness -a cross-sectional cohort study.

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Yelden, K; Duport, S; James, LM; Kempny, A; Farmer, SF; Leff, AP; Playford, ED; (2017) Late recovery of awareness in prolonged disorders of consciousness -a cross-sectional cohort study. Disabil Rehabil pp. 1-6. 10.1080/09638288.2017.1339209 . http://ift.tt/2sA6KH2

Endoscopic Depth Measurement and Super-Spectral-Resolution Imaging

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Lin, J; Clancy, NT; Hu, Y; Qi, J; Tatla, T; Stoyanov, D; Maier-Hein, L; Lin, J; Clancy, NT; Hu, Y; Qi, J; Tatla, T; Stoyanov, D; Maier-Hein, L; Elson, DS; – view fewer Endoscopic Depth Measurement and Super-Spectral-Resolution Imaging. http://ift.tt/2t4PYDp

Fast Estimation of Haemoglobin Concentration in Tissue Via Wavelet Decomposition

Alexandros SfakianakisστοMedicine by Sfakianakis AlexandrosΠριν από 22 ώρες
Jones, G; Clancy, NT; Du, X; Robu, M; Arridge, S; Elson, DS; Stoyanov, D; Fast Estimation of Haemoglobin Concentration in Tissue Via Wavelet Decomposition. http://ift.tt/2sAeZDi

The Effects of Cognitive Reappraisal on Conditioned Disgust in Contamination-based OCD: An Analogue Study

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 23 ώρες
[image: S08876185.gif] Publication date: Available online 1 July 2017 *Source:*Journal of Anxiety Disorders Author(s): Bunmi O. Olatunji, Hannah Berg, Rebecca C. Cox, Amber Billingsley Experimental research has shown that conditioned disgust is resistant to extinction, which may account for the slower habituation to disgust relative to fear in contamination-based obsessive-compulsive disorder (OCD). However, few studies have examined the efficacy of interventions that may attenuate conditioned disgust responses. Studies of cognitive reappraisal have demonstrated that reinterpreting a… περισσότερα »

Meditation is associated with increased brain network integration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 23 ώρες
[image: S10538119.gif] Publication date: September 2017 *Source:*NeuroImage, Volume 158 Author(s): Remko van Lutterveld, Edwin van Dellen, Prasanta Pal, Hua Yang, Cornelis Jan Stam, Judson Brewer IntroductionThis study aims to identify novel quantitative EEG measures associated with mindfulness meditation. As there is some evidence that meditation is associated with higher integration of brain networks, we focused on EEG measures of network integration.MethodsSixteen novice meditators and sixteen experienced meditators participated in the study. Novice meditators performed a basic m… περισσότερα »

Uncategorized

The dog days or dog days of summer are the hot, sultry days of summer. They were historically the period followi ng the heliacal rising of the star Sirius, which Greek and Roman astrology connected with heat, drought, sudden thunders torms, lethargy, fever, mad dogs, and bad luck. They are now taken to be the hottest, most uncomfortable part of summer in the Northern Hemisphere.Achilles’ approach towards Troy, where he will slay Hector, is illustrated through an extende d metaphor about the baleful effects attending the return of Sirius: τὸν δ᾽ ὃ γέρων Πρίαμος πρῶ τος ἴδεν ὀφθαλμοῖσι παμφαίνονθ᾽ ὥς τ᾽ ἀστέρ᾽ ἐπεσσύμενον πε δίοιο, ὅς ῥά τ᾽ ὀπώρης εἶσιν, ἀρίζηλοι δέ οἱ αὐγαὶ φαίνονται π ολλοῖσι μετ᾽ ἀστράσι νυκτὸς ἀμολγῷ, ὅν τε κύν᾽ Ὠρίωνος ἐπίκ λησιν καλέουσι. λαμπρότατο

Dog days

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This article is about the weather-related phrase. For other uses, see Dog Days (disambiguation).

Lilies in the late July heat, Lemnos, Greece.

The dog days or dog days of summer are the hot, sultry days of summer. They were historically the period following the heliacal rising of the star Sirius, which Greek and Roman astrology connected with heat, drought, sudden thunderstorms, lethargy, fever, mad dogs, and bad luck. They are now taken to be the hottest, most uncomfortable part of summer in the Northern Hemisphere.

Contents

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Name[edit]


In addition to following Orioninto the night sky, the Dog Star Sirius can be easily located in the heavens by following the line created by the prominent asterismOrion’s Belt.

The English name is a calque of the Latin dies caniculares (lit. "the puppy days"), itself a calque of the Greekkynádes hēmérai (κυνάδες ἡμέραι, "dog days").[1] The Greeks knew the star α Canis Majoris by several names, including Sirius (Σείριος, Seírios, "Scorcher"), Sothis (Σῶθις, Sôthis, a transcription of Egyptian Spdt), and the Dog Star (Κῠ́ων, Kúōn).[2] The last name reflects the way Sirius follows the constellation Orion into the night sky.[3]

History[edit]

Sirius is by far the brightest proper star in the night sky, which caused ancient astronomers to take note of it around the world. In Egypt, its return to the night sky became known as a precursor of the annual flooding of the Nile and was worshipped as the goddess Sopdet. In Greece, whose higher latitude caused it to appear several days later, it instead became known as the precursor of the unpleasantly hot phase of the summer. Their poetseven record the belief that the return of the bright star was responsible for bringing heat and fever with it.[4] It was also associated with sudden thunderstorms.[5] In Homer‘s Iliad, probably composed in the 8th century bcbut representing an earlier tradition,[6]Achilles‘ approach towards Troy, where he will slay Hector, is illustrated through an extended metaphor about the baleful effects attending the return of Sirius:

τὸν δ᾽ ὃ γέρων Πρίαμος πρῶτος ἴδεν ὀφθαλμοῖσι
παμφαίνονθ᾽ ὥς τ᾽ ἀστέρ᾽ ἐπεσσύμενον πεδίοιο,
ὅς ῥά τ᾽ ὀπώρης εἶσιν, ἀρίζηλοι δέ οἱ αὐγαὶ
φαίνονται πολλοῖσι μετ᾽ ἀστράσι νυκτὸς ἀμολγῷ,
ὅν τε κύν᾽ Ὠρίωνος ἐπίκλησιν καλέουσι.
λαμπρότατος μὲν ὅ γ᾽ ἐστί, κακὸν δέ τε σῆμα τέτυκται,
καί τε φέρει πολλὸν πυρετὸν δειλοῖσι βροτοῖσιν:
ὣς τοῦ χαλκὸς ἔλαμπε περὶ στήθεσσι θέοντος.

Priam saw him first, with his old man’s eyes,
A single point of light on Troy’s dusty plain.
Sirius rises late in the dark, liquid sky
On summer nights, star of stars,
Orion’s Dog they call it, brightest
Of all, but an evil portent, bringing heat
And fevers to suffering humanity.
Achilles’ bronze gleamed like this as he ran.[7]

The rising of Sirius during this period has been calculated as 19 July (Julian).[8] Writing about the same time,[9]Hesiod, however, considered that the worst and hottest part of the summer were the days before Sirius returned to the night sky. During this period, Sirius was invisible from the earth but it was apparently understood to still be in the sky, augmenting the power of the sun:


Trees and grass on Crete dried out by the August heat

ἦμος δὴ λήγει μένος ὀξέος ἠελίοιο
καύματος ἰδαλίμου, μετοπωρινὸν ὀμβρήσαντος
Ζηνὸς ἐρισθενέος, μετὰ δὲ τρέπεται βρότεος χρὼς
πολλὸν ἐλαφρότερος: δὴ γὰρ τότε Σείριος ἀστὴρ
βαιὸν ὑπὲρ κεφαλῆς κηριτρεφέων ἀνθρώπων
ἔρχεται ἠμάτιος, πλεῖον δέ τε νυκτὸς ἐπαυρεῖ:
τῆμος ἀδηκτοτάτη πέλεται τμηθεῖσα σιδήρῳ
ὕλη, φύλλα δ᾽ ἔραζε χέει, πτόρθοιό τε λήγει:
τῆμος ἄρ᾽ ὑλοτομεῖν μεμνημένος ὥρια ἔργα.

When the piercing power and sultry heat of the sun abate, and almighty Zeus sends the autumn rains, and men’s flesh comes to feel far easier,—for then the star Sirius passes over the heads of men, who are born to misery, only a little while by day and takes greater share of night—then, when it showers its leaves to the ground and stops sprouting, the wood you cut with your axe is least liable to worm.[10]

This effect of the combination of Sirius’s light with the Sun’s was understood to have an effect on plants, animals, and women, as well as men:

ἦμος δὲ σκόλυμός τ᾽ ἀνθεῖ καὶ ἠχέτα τέττιξ
δενδρέῳ ἐφεζόμενος λιγυρὴν καταχεύετ᾽ ἀοιδὴν
πυκνὸν ὑπὸ πτερύγων, θέρεος καματώδεος ὥρῃ,
τῆμος πιόταταί τ᾽ αἶγες καὶ οἶνος ἄριστος,
μαχλόταται δὲ γυναῖκες, ἀφαυρότατοι δέ τοι ἄνδρες
εἰσίν, ἐπεὶ κεφαλὴν καὶ γούνατα Σείριος ἄζει,
αὐαλέος δέ τε χρὼς ὑπὸ καύματος…

But when the artichoke flowers, [i.e., June] and the chirping grass-hopper sits in a tree and pours down his shrill song continually from under his wings in the season of wearisome heat, then goats are plumpest and wine sweetest; women are most wanton, but men are feeblest, because Sirius parches head and knees and the skin is dry through heat.[11]

About a century later, Alcaeus repeated the theme, advising his listeners to "steep your lungs in wine" before the arrival of the star since "women are at their foulest but men are weak since they are parched in head and knees".[12] In the 3rd century, Aratus‘s Phenomena describes the time Sirius blighting the bark of trees with its heat during the time it rises and sets with the sun.[13]

The Kean priests of Zeus as Rainmaker and Lord of Moisture[14] observed annual sacrifices before the rise of Sirius to prevent scorching drought.[15][16] This practice was credited to the culture hero Aristaeus.[15][17][18][19]Aristotle mentions the proverbial heat of the dog days as part of his argument against an early formulation of evolution in his Physics.[20]


A 9th-century astronomical manuscript, including an illustration of the constellation "Sirius"[21]

The Romans continued to blame Sirius for the heat of the season and attendant lethargy and diseases.[5] In his Georgics, Vergil notes vintners’ efforts to protect their work during the time "when the Dog-star cleaves the thirsty Ground".[22]Seneca‘s Oedipus complains of "the scorching dog-star’s fires".[23]Pliny‘s Natural Historynotes an increase in attacks by dogs during July and August and advises feeding them chicken shit to curb the tendency.[5] In the early 20th century, historians still noted the "discouraging heat" and "oppression" of the dog days of the Roman summer.[24]

The period long featured in western medicine. The 1564 English Hope of Health counseled that purging (bloodletting and induced vomiting) should be avoided during the "Dogge daies" of summer because "the Sunne is in Leo" and "then is nature burnt vp & made weake".[25] The 1729 British Husbandman’s Practiceclaimed that "The Heat of the Sun is so violent that Men’s bodies at Midnight sweat as at Midday: and if they be hurt, they be more sick than at any other time, yea very near Dead". It therefore advised men to "abstain all this time from women" and to "take heed of feeding violently".[5] In the 1813 Clavis Calendria, the dog days are a time wherein "the Sea boiled, the Wine turned sour, Dogs grew mad, and all other creatures became languid; causing to man, among other diseases, burning fevers, hysterics, and phrensies".[26]


"Some Popular Alleviations of the Dog Days in Hotter New-York" in 1904, including children piled into a public fountain "when the ‘cop’ is not looking".[27]

Even after astrology and its influence on health and agriculture waned in importance, the "dog days" continues to be vaguely applied to the hottest days of the summer, with its attendant effects on nature and society. In North America, it became proverbial among farmers that a dry growing season through the dog days was preferable to the trouble of a wet one:

Dog days bright and clear
Indicate a good year;
But when accompanied by rain,
We hope for better times in vain.[29]

Because "July is typically one of the quietest months of the year for stock trading", the term is sometimes used for the lethargic summer markets.[5][30]

Span[edit]

Various computations of the dog days have placed their start anywhere from 3 July to 15 August and lasting for anywhere from 30 to 61 days.[1] They may begin or end with the cosmical or heliacal rising of either Sirius in Canis Major or Procyon (the "Little Dog Star") in Canis Minor and vary by latitude, not even being visible throughout much of the Southern Hemisphere.[1] Sirius observes a period of almost exactly 365¼ days between risings, keeping it largely consistent with the Julian but not the Gregorian calendar; nonetheless, its dates occur somewhat later in the year over a span of millennia.[1]

In antiquity, the dog days were usually reckoned from the appearance of Sirius[2] around 19 July (Julian)[8] to relieving rains and cool winds, although Hesiod seems to have counted the worst of summer as the days leading up to Sirius’s reappearance.[10]

In Anglo-Saxon England, the dog days ran from various dates in mid-July to early or mid-September.[31] Canonical "dog daies" were observed from July 7 to September 5 in the 16th-century English liturgies.[32][33] They were removed from the prayer books at the restoration of the monarchy in 1660 and their term shortened to the time between July 19 and August 20.[34] During the British adoption of the Gregorian calendar in 1752, they were shifted to July 30 to September 7.[34]

Many modern sources in the English-speaking world move this still earlier, from July 3 to August 11,[1][34][35][5] ending rather than beginning with or centering on the reappearance of Sirius to the night sky.

Scientific basis[edit]


Orion (right) and Sirius (bottom), as seen from the Hubble Space Telescope.

Although Sirius is the brightest proper star in the night sky, it is 8.7 light-years (8.23×1013 km) away from Earth and it has no effect whatsoever on the weather or temperature.[5][36] Although the star continues to return to the night sky in the late summer, its position continues to slowly shift relative to the sun and will rise in the middle of winter in about 10,000 years.[5]

The effects of summer heat and rainfall patterns are real, but vary by latitude and location according to many factors. For example, London in the UK is farther north than Calgary, Canada, but has a milder climate from the presence of the sea and the warm Gulf Stream current. A medical institution has reported a connection between Finland‘s dog days and increased risk of infection in deep surgery wounds,[37][38] although that research remains unverified.

In popular culture[edit]


Harry Clarke‘s 1917 illustration of Synge‘s poem.

It is possible that the Roch, the legendary medieval patron saint of dogs celebrated by the Catholic Church on 16 August, owes some of his legacy to the dog days.[5] From the period of his self-proclaimed protectorate over the island, the Danish adventurer Jørgen Jürgensen is remembered in Iceland as Jorgen the Dog-Day King (Icelandic: Jörundur hundadagakonungur).[39]

In western literature, apart from the Greek and Roman works mentioned above, the dog days appear in John Webster‘s 1613 play The Duchess of Malfi,[a]Charles Dickens‘s 1843 novella A Christmas Carol,[b]R.H. Davis‘s 1903 short story "The Bar Sinister",[c]J.M. Synge‘s 1909 poem "Queens",[d] and Richard Adams‘s 1972 novel Watership Down.[e] They feature in the children’s novels Dog Days[45] and Tuck Everlasting.[f]

In film, the titles of Dog Day Afternoon (1975) and Hundstage (German for "Dog Days"; 2001) evoke their oppressive seasonal settings.[47][48]

In music, there are Head of David‘s "Dog Day Sunrise", covered by Fear Factory in 1995; Florence and the Machine‘s 2009 "Dog Days Are Over";[49] and Within Temptation‘s 2013 "Dog Days".

"Dog-day" promotions are also a common feature in baseball, used by American ballparks to boost ticket sales during mid-afternoon games.[5]

See also[edit]

Look up dog days in Wiktionary, the free dictionary.

Notes[edit]

  1. Jump up^ Bosola states that "blackbirds fatten best in hard weather: why not I in these dog days?"[40]
  2. Jump up^ Ebenezer Scrooge is described as "carr[ying] his own low temperature always about with him" to the point where "he iced his office in the dog-days".[41]
  3. Jump up^ The main character, a street dog, opines that "when the hot days come… they might remember that those are the dog days, and leave a little water outside… like they do for the horses".[42]
  4. Jump up^ The poem opens:

    Seven dog-days we let pass
    Naming Queens in Glenmacnass…[43]

  5. Jump up^ Describing the English summer, Adams writes "Now came the dog days—day after day of hot, still summer, when for hours at a time light seemed the only thing that moved; the sky-sun, clouds and breeze-awake above the drowsing downs.[44]
  6. Jump up^ Describing the book’s setting in the first week of August, the prologue speaks of "strange and breathless days, the dog days, when people are led to do things they are sure to be sorry for after".[46]

References[edit]

Citations[edit]

  1. ^ Jump up to:a b c d e "dog day, n.", Oxford English Dictionary, Oxford: Oxford University Press.
  2. ^ Jump up to:a b "Dog Star, n.", Oxford English Dictionary, Oxford: Oxford University Press.
  3. Jump up^ McHugh (2004), p. 43.
  4. Jump up^ Holberg (2007), pp. 15–6.
  5. ^ Jump up to:a b c d e f g h i j Kelly & al. (2009), p. 59.
  6. Jump up^ For details, see the Homeric Question.
  7. Jump up^ Lombardo (1997), Bk. XXII, ll. 33–37.
  8. ^ Jump up to:a b Edwards (2004), pp. 152–153.
  9. Jump up^ For details, see Hesiod § Dating.
  10. ^ Jump up to:a b Evelyn-White (1914), ll. 414–422.
  11. Jump up^ Evelyn-White (1914), ll. 582–588.
  12. Jump up^ Miller (1996), Frag. 357.
  13. Jump up^ Aratus, Phenomena, ll. 328 ff.
  14. Jump up^ Atsma, Aaron J., "Seirios", The Theoi Project.
  15. ^ Jump up to:a b Apollonius of Rhodes, Argonautica, Bk. II, ll. 518 ff.
  16. Jump up^ Callimachus, Aetia, fragment on Oxyrhynchus Papyrus 7.
  17. Jump up^ Diodorus of Sicily, Bibliotheca Historica, Bk. IV, §81.
  18. Jump up^ Pseudo-Hyginus, De Astronomica, Bk. II, §4.
  19. Jump up^ Nonnus of Panopolis, Dionysiaca, Bk. XIII, ll. 253 ff.
  20. Jump up^ Hardie & al. (1930), Bk. II, Pt. 8.
  21. Jump up^ BL Harley MS 647, f. 8 v.
  22. Jump up^ Dryden (1697), p. 85.
  23. Jump up^ Miller (1917).
  24. Jump up^ Carter (1911), p. 247.
  25. Jump up^ Moore (1564), f. 58 v..
  26. Jump up^ Brady (1813), p. 84.
  27. Jump up^ "Some Popular Alleviations of the Dog Days in Hotter New-York", New-York Tribune, New York, 7 August 1904.
  28. Jump up^ Dunwoody (1883), p. 98.
  29. Jump up^ Recorded in 1883 by Dunwoody.[28]
  30. Jump up^ Strumpf, Dan (1 August 2014), "Markets: Dog Days of Summer for Stock Trading", The Wall Street Journal.
  31. Jump up^ Chardonnens (2007), p. 289.
  32. Jump up^ "The Table and Kalendar…", The Boke of Common Prayer…, London: Edward Whytchurche, 1552.
  33. Jump up^ "The Table and Kalendar…", The Boke of Common Praier…, London: Richard Grafton, 1559.
  34. ^ Jump up to:a b c Townsend (1862), "Dog-days".
  35. Jump up^ OFA (2017), "The Dog Days Begin".
  36. Jump up^ For details, see Astrology.
  37. Jump up^ Tukiainen, E.; et al. (March 2009), "‘Dog Days’ Surgical Site Infections in a Finnish Trauma Hospital during 2002–2005", Journal of Hospital Infection, Vol. 71, No. 3, pp. 290–291, PMID 19157647, doi:10.1016/j.jhin.2008.11.010.
  38. Jump up^ Tukiainen, E.; et al. (March 2009), "Infektiot Yleisempiä Mätäkuussa [Infections Common in the 'Rotten Month']", Duodecim, Vol. 125, No. 13, pp. 1415–1420, PMID 19678497 (in Finnish). See also this abstract in Finnish and English.
  39. Jump up^ "Hver Var Jörundur Hundadagakonungur og Hvað Var Hann að Gera á Íslandi?", Vísindavefurinn, retrieved 2 December 2015. (in Icelandic)
  40. Jump up^ Webster (1613), Act I, Sc. i, l. 34.
  41. Jump up^ Dickens (1843), p. 2.
  42. Jump up^ Staudohar (2007), p. 187.
  43. Jump up^ Synge (1909).
  44. Jump up^ Adams (1972), p. 53.
  45. Jump up^ Kinney (2009).
  46. Jump up^ Babbitt (1975), p. 3.
  47. Jump up^ Hoberman, J. (15 October 2015), "Lumet’s ‘Dog Day Afternoon’: Hot Crime, Summer in the City", New York Times.
  48. Jump up^ Bradshaw, Peter (17 November 2001), "Dog Days", The Guardian.
  49. Jump up^ Barrett, Pete, Florence and the Machine—Dog Days Are Over Single Review, Contact Music.

Bibliography[edit]

Uncategorized

Medicine A

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Medicine Sfakianakis G. Alexandros
Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function
We have recently demonstrated that mycobacterial ligands engage Toll like receptor 2 (TLR2) on CD4+ T cells and up-regulate T-cell receptor (TCR) triggered Th1 responses in vitro and in vivo. To better understand the role of T-cell expressed TLR2 on CD4+ T-cell differentiation and function, we conducted…

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
15:50

Medicine Sfakianakis G. Alexandros
Extracellular vesicles mediate intercellular communication: Transfer of functionally active microRNAs by microvesicles into phagocytes
Cell activation and apoptosis lead to the formation of extracellular vesicles (EVs) such as exosomes or microvesicles (MVs). EVs have been shown to modulate immune responses; recently, MVs were described to carry microRNA (miRNA) and a role for MVs in the pathogenesis of autoimmune diseases has been…

otorhinolaryngologysfakianakisal.blogspot.com?w=16&cs=3807766444
15:50

OtorhinolaryngologySfakianakis
Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy
Publication date: Available online 29 June 2017Source:Photodiagnosis and Photodynamic Therapy Author(s): Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira, Sabrina Barbosa de Souza Ferreira, Larissa Lachi Silva, Bruno Ribeiro Rabello, Lidiane Vizioli de Castro, Mauro Luciano Baesso, Andréa…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Dickkopf-4 is frequently overexpressed in epithelial ovarian carcinoma and promotes tumor invasion
Abstract Background Dickkopf-4 (DKK4), a member of DKK family, appears to be a divergent protein. It remained multi-biological functions in carcinogenesis. The effect of DKK4 on the ovarian cancer cells remains unclear. This study…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Optimizing the treatment of bevacizumab as first-line therapy for human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer: an updated meta-analysis of published randomized trials
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cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Clinical importance of serum HE4 and MMP2 levels in endometrial cancer patients
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cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors
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cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Patients harboring ALK rearrangement adenocarcinoma after acquired resistance to crizotinib and transformation to small-cell lung cancer: a case report
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cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
RE: “RISK PREDICTION FOR EPITHELIAL OVARIAN CANCER IN 11 UNITED STATES–BASED CASE-CONTROL STUDIES: INCORPORATION OF EPIDEMIOLOGIC RISK FACTORS AND 17 CONFIRMED GENETIC LOCI”
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cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Protecting Confidentiality in Cancer Registry Data With Geographic Identifiers
AbstractThe National Cancer Institute’s Surveillance, Epidemiology, and End Results Program releases research files of cancer registry data. These files include geographic information at the county level, but no finer. Access to finer geography, such as census tract identifiers, would enable richer analyses—for…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
RE: “ASSOCIATIONS OF ACCELEROMETRY-ASSESSED AND SELF-REPORTED PHYSICAL ACTIVITY AND SEDENTARY BEHAVIOR WITH ALL-CAUSE AND CARDIOVASCULAR MORTALITY AMONG US ADULTS”
In the article “Associations of Accelerometry-Assessed and Self-Reported Physical Activity and Sedentary Behavior With All-Cause and Cardiovascular Mortality Among US Adults” by Evenson et al. (1), the units of measure for screen time were incorrectly listed as hours/week and MET-hours/week in Tables…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Skin Pigmentation and Risk of Hearing Loss in Women
AbstractBlack individuals have a lower risk of hearing loss than do whites, possibly because of differences in cochlear melanocytes. Previous studies have suggested that darker-skinned individuals tend to have more inner ear melanin, and cochlear melanocytes are important in generating the endocochlear…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
RE: “MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY”
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cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Association Between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status The Northern Manhattan Study
AbstractWe hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Cigarette Smoking and Risk of Incident Rosacea in Women
AbstractThe relationship between smoking and rosacea is poorly understood. We aimed to conduct the first cohort study to determine the association between smoking and risk of incident rosacea. We included 95,809 women from Nurses’ Health Study II (1991–2005). Information on smoking was collected biennially…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Modeling Seasonal and Spatiotemporal Variation: The Example of Respiratory Prescribing
AbstractMany measures of chronic diseases, including respiratory disease, exhibit seasonal variation together with residual correlation between consecutive time periods and neighboring areas. We demonstrate a strategy for modeling data that exhibit both seasonal trend and spatiotemporal correlation,…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Time-Dependent Associations Between Body Composition, Physical Activity, and Current Asthma in Women: A Marginal Structural Modeling Analysis
AbstractThe role of obesity in adult asthma is well-known and has been partly attributed to a confounding role of physical inactivity. However, the interrelationships between obesity, physical activity, and asthma have been incompletely addressed, probably because their time-dependent and bidirectional…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes
AbstractMaternal diabetes is associated with congenital heart defects (CHDs) as a group, but few studies have assessed risk for specific CHD phenotypes. We analyzed these relationships using data from the Texas Birth Defects Registry and statewide vital records for deliveries taking place in 1999–2009…

cancersfakianakis.tumblr.com?w=16&cs=562404105
15:49

Cancer by Sfakianakis G.Alexandros
RE: “RESPONSE AND FOLLOW-UP BIAS IN COHORT STUDIES”
In the article “Response and Follow-up Bias in Cohort Studies” by Greenland (1), there is a missing decimal point in the first footnote of Table 3. The risk ratio of 70 should be 0.70. from Cancer via xlomafota13 on Inoreader http://ift.tt/2trLoQR via IFTTT

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
Neuropsychiatry phenotype in asthma: Psychological stress-induced alterations of the neuroendocrine-immune system in allergic airway inflammation
Publication date: Available online 29 June 2017Source:Allergology International Author(s): Isao OhnoSince the recognition of asthma as a syndrome with complex pathophysiological signs and symptoms, recent research has sought to classify asthma phenotypes based on its clinical and molecular pathological…

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
CME Activities Calendar
▪ AAAAI QCDR for Practice Improvement 2017http://ift.tt/2t8oxr3

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15:47

OtoRhinoLaryngology – Head and Neck Surgery
Cover 1
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earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
News & Notes
Are you seeking additional training in the causes and mechanisms of atopic and contact dermatitis? Need to enhance your overall hands-on skills to accurately apply patch tests and interpret the results? Mark your calendar for the new, live course “Eczema and Contact Dermatitis in the Allergy/Immunology…

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
Brief Overview of This Month’s JACI
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earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
News Beyond Our Pages
Infection with respiratory syncytial virus (RSV) during infancy has been linked to increased risk for later onset of asthma. Additionally, prophylactic use within the first year of life of palivizumab, an mAb directed against the RSV fusion glycoprotein, protects against chronic wheezing through the…

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
An exposome perspective: Early-life events and immune development in a changing world
Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a new emphasis in research; interdisciplinary work suggests that personalized medicine is on the horizon. These advances are illuminating sophisticated interactions between human-associated microbes and the immune system….

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
The environment, epigenome, and asthma
Asthma prevalence has been on the increase, especially in North America compared with other continents. However, the prevalence of asthma differs worldwide, and in many countries the prevalence is stable or decreasing. This highlights the influence of environmental exposures, such as allergens, air pollution,…

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
Environmental determinants of allergy and asthma in early life
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earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
The Editors’ Choice
Perturbations or “dysbiosis” of the bronchial microbiota have been implicated in the pathogenesis of asthma. However, it remains unclear whether reported differences are reflective of atopy, a common comorbidity of asthma. In a National Heart, Lung, and Blood Institute AsthmaNet study of well-characterized…

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
The Journal of Allergy and Clinical Immunology: An update on style and substance
Our stewardship of the Journal of Allergy and Clinical Immunology (JACI) is now in its sophomore year.1 In this short time, we have had the privilege of working with our authors and readers and have endeavored to respond to your concerns and suggestions. We have instituted several changes in our quest…

earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
Information for Readers
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earnosethroatmedicinesfakianakis.tumblr.com?w=16&cs=1933801890
15:47

OtoRhinoLaryngology – Head and Neck Surgery
Correction
With regard to the article in the July 2016 issue entitled “Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis” (J Allergy Clin Immunol 2016;138:187-99), it has been brought to the Editors’ attention that Fig 1 was incorrect as printed….

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15:47

OtoRhinoLaryngology – Head and Neck Surgery
Table of Contents
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15:47

OtoRhinoLaryngology – Head and Neck Surgery
Editorial Board
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medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
15:46

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Cells, Vol. 6, Pages 17: Standard Immunohistochemical Assays to Assess Autophagy in Mammalian Tissue
Autophagy is a highly conserved lysosomal degradation pathway with major impact on diverse human pathologies. Despite the development of different methodologies to detect autophagy both in vitro and in vivo, monitoring autophagy in tissue via immunohistochemical techniques is hampered due to the lack…

sfakianakis1.blogspot.com?w=16&cs=1240409760
15:43

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Increase in Hospital Discharges for Inflammatory Bowel Diseases in Chile Between 2001 and 2012
Abstract Aim To determine the number of annual hospital discharges for inflammatory bowel diseases in Chile. The hypothesis is that there is a significant increase in the hospital discharges due to this disease from 2001 to 2012. Materials and Methods This is a descriptive study. Data were obtained…

headandneckdiseases.blogspot.com?w=16&cs=2341930686
15:42

Head and Neck Diseases by Alexandros G.Sfakianakis
Evolution of Spitz Nevi
Abstract Background/Objectives Spitz nevi are melanocytic lesions with clinical, dermoscopic, and histopathologic presentations that may resemble those of melanoma. The evolution of Spitz nevi is a well-known feature. The objectives of this study were to investigate the clinical and dermoscopic…

iatrikisfakianakis.tumblr.com?w=16&cs=974219413
15:41

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Photo-Induced Bending Behavior of Post-Crosslinked Liquid Crystalline Polymer/Polyurethane Blend Films
Photoresponsive blend films with post-crosslinked liquid crystalline polymer (CLCP) as a…

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Prehospital parameters can help to predict coagulopathy and massive transfusion in trauma patients
Vox Sanguinisfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trgA2y

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
US Senate health bill would decimate long-term care coverage
Reuters Health Newsfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trExqr

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Reconstruction of AAOS type III and IV acetabular defects with the Ganz reinforcement ring: High failure in pelvic discontinuity
Archives of Orthopaedic and Trauma Surgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2tryi63

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Cancer researchers may overestimate reliability of mouse studies
Reuters Health Newsfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8LGrN

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Concussion assessment recommendations not followed during last World Cup, research finds
St. Michael’s Hospitalfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8Cp3f

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Smoking is a risk factor for proliferative vitreoretinopathy after traumatic retinal detachment
Retinafrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trKrYS

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Markedly increased incidence of critical illness in adults with Type 1 diabetes
Diabetic Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trKqEi

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
US FDA outlines plan to speed rare disease drug reviews
Reuters Health Newsfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8Za6Y

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Patient-proxy agreement on the health-related quality of life one year after traumatic brain injury
Archives of Physical Medicine and Rehabilitationfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trgxno

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Intraoperative cholangiography during cholecystectomy among hospitalized Medicare beneficiaries with non-neoplastic biliary disease
The American Journal of Surgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trGGCG

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Impact of a cardiac intensivist on mortality in patients with cardiogenic shock
International Journal of Cardiologyfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8FaBo

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Effect of bariatric surgery on emergency department visits and hospitalizations for atrial fibrillation
The American Journal of Cardiologyfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8CuE5

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Risk factors for early return visits to the emergency department in patients with urinary tract infection
The American Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s98szM

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Salvage of failed ankle arthrodesis after posttraumatic septic arthritis by Ilizarov external fixator: Mid-term results
Current Orthopaedic Practicefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trFXBx

emergencymedicineas.blogspot.com?w=16&cs=3457582281
15:40

Emergency Medicine by Alexandros G. Sfakianakis
Pain intensity, interference, and medication use after spinal cord injury: relationship with risk of mortality after controlling for socioeconomic and other health factors
Archives of Physical Medicine and Rehabilitationfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8OJAu

Uncategorized

Medicine

cancersfakianakis1.tumblr.com?w=16&cs=3000829352
16:17

Oncology
Left hepatectomy after right paramedian sectoriectomy
Abstract Repeat hepatectomy is beneficial for selected patients with recurrence of liver malignancies. However, the operative procedure becomes technically demanding when the previous hepatectomy was complex, with hepatic veins and stump of portal pedicles exposed on the liver transection…

cancersfakianakis1.tumblr.com?w=16&cs=3000829352
16:17

Oncology
Natural history of intramedullary spinal cord ependymoma in patients preferring nonoperative treatment
Abstract Surgical resection of intramedullary spinal cord ependymoma still remains the standard of care but is challenging and occasionally associated with poor outcome. The aim of this study is therefore to provide additional information regarding the natural history of conservatively…

cancersfakianakis1.tumblr.com?w=16&cs=3000829352
16:17

Oncology
Reduction in Social Activities Mediates the Relationship between Diarrhea and Distress in Rectal/Anal Cancer Survivors
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cancersfakianakis1.tumblr.com?w=16&cs=3000829352
16:17

Oncology
Understanding how Coping Strategies and Quality of Life maintain Hope in Patients deliberating Phase-I Trial Participation
Abstract ObjectiveThis study aimed to understand how hope and motivation of patients considering phase-I trial participation are affected by psychological factors such as coping strategies and locus of control (LoC), and general well-being as measured by the quality of life (QoL). MethodsAn exploratory…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:17

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Doctors commended for their bravery in response to terrorist incidents
Two doctors have been commended for "running towards danger" in response to terrorist incidents in London and Manchester.12Jeeves Wijesuriya, a GP trainee and chair of the BMA Junior Doctors’… from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader…

sfakianakis1.blogspot.com?w=16&cs=1240409760
16:16

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Assessing the Therapeutic Utility of Professional Continuous Glucose Monitoring in Type 2 Diabetes Across Various Therapies: A Retrospective Evaluation
Abstract Background There have been few large studies that have analyzed the effect of professional (masked) continuous glucose monitoring (P-CGM) on glycemic control in patients with type 2 diabetes (T2DM) who were on a broad spectrum of baseline therapies. Methods We performed a retrospective,…

sfakianakis1.blogspot.com?w=16&cs=1240409760
16:16

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After Penetrating and Posterior Lamellar Keratoplasty: A Retrospective Clinical Observation
Abstract Introduction The aim of this observational study is to evaluate the effectiveness of an adjuvant intracameral corticosteroid injection (ICI) in cases of severe endothelial immune reaction (SEIR) (anterior chamber cells and flare, retrocorneal precipitates, Descemet’s folds, and corneal edema)…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:15

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Sixty seconds on . . . the CEP
The what?You know, the CEP. Close friend of the STP, the IFR, and the RTT. It’s the capped expenditure process—another lovely phrase straight from the NHS Acronym Referral Site for England… from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:15

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
La sfida per l’Internet del futuro – La Stampa
La sfida per l’Internet del futuroLa Stampa I recenti progressi nel campo dell’intelligenza artificiale e dell’Internet delle cose sono essenziali per trasformare l’aumento inarrestabile delle informazioni in conoscenza, per unire il mondo fisico e quello virtuale e per integrare autonomia e…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:15

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Find the flow: Harnessing the incredible power of living fluids
We’re beginning to learn the rules that govern how everything from flocks of birds to sperm cells flow, and it could transform technology and medicine from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2u607yh via IFTTT

medicinebyalexandros.blogspot.com?w=16&cs=654263150
16:14

Medicine by Alexandros G.Sfakianakis
Magnetic Resonance Imaging and Clinical Features in Acute and Subacute Myelopathies
Abstract Differential diagnosis of acute and subacute transverse myelopathy includes inflammatory, infectious, vascular, metabolic and paraneoplastic etiologies. Information on the diagnostic approach to transverse myelopathy with regard to daily clinical practice is provided. The differentiation between…

scholarmedsfakianakis.blogspot.com?w=16&cs=1684924305
16:14

ΩΡΛ Ιατρικά Άρθρα απ’ το Μελετητή
Scholar : These new articles for Advanced Robotics are available online
The online platform for Taylor & Francis Online content New for Advanced Robotics and online now on Taylor & Francis Online: Full paper High path tracking control of an intelligent walking-support robot under time-varying friction and unknown parameters…

cancerologyoncologysfakianakis.wordpress.com?w=16&cs=2589301554
16:13

Cancerology Oncology
Preoperative fasting in children
1A012A033J03 http://ift.tt/2tttpsJ

iatrikisfakianakis.tumblr.com?w=16&cs=974219413
16:12

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Augmenix debuts SpaceOar in Israel
Augmenix Inc. said this week that it launched its SpaceOar hydrogel device in Israel. The Bedford,…

iatrikisfakianakis.tumblr.com?w=16&cs=974219413
16:12

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Shareholders revive class-action kickbacks suit against Cardiovascular Systems
Shareholders revived a purported class-action kickbacks lawsuit against Cardiovascular…

iatrikisfakianakis.tumblr.com?w=16&cs=974219413
16:12

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Roche buys mySugr diabetes app
Swiss drugmaker Roche (PINK:RHHBY) said today that it bought diabetes management platform mySugr for…

iatrikisfakianakis.tumblr.com?w=16&cs=974219413
16:12

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Congenital neonatal scalp arteriovenous malformation: a very rare entity
Congenital arteriovenous malformations (AVMs) of scalp are rare congenital vascular malformations….

iatrikisfakianakis.tumblr.com?w=16&cs=974219413
16:12

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
A case of acute confusion: Cushings syndrome presenting with primary hyperparathyroidism
Cushing’s syndrome is a rare disease. Cushing’s syndrome presenting as acute psychosis is an…

iatrikisfakianakis.tumblr.com?w=16&cs=974219413
16:12

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
The Spontaneous Adhesion of BMMC onto Self-Assembled Peptide Nanoscaffold without Activation Inhibits Its IgE-Mediated Degranulation
Mast cells play a distinct role in the innate immune response. Engineered microenvironments for the…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:12

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Development of a pneumatic soft actuator with pleated inflatable structures
. from ! Medicine by Alexandros G. Sfakianakis via Αλέξανδρος Σφακιανάκης on Inoreader http://ift.tt/2txq251 via IFTTT

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:12

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Medicine Sfakianakis G. Alexandros
Ροές που μπορεί να σας αρέσουν Να μην εμφανιστεί αυτό ξανά Cardiovascular / Cardiology News From Medical News Today Latest Health News and Medical News posted throughout the day, every day. OtoRhinoLaryngology – Alexandros…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:03

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
RT @CarrascalAlvaro : "..pats are their own best Drs., & engag. them in their care is not an emotion. ideal, but an impactful interv. w/ rea…
RT @CarrascalAlvaro : "..pats are their own best Drs., & engag. them in their care is not an emotion. ideal, but an impactful interv. w/ rea… from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/880761554051923968 via IFTTT

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:03

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Jason Read: The Politics of Transindividuality
from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2sYe5nm via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:02

Medicine Sfakianakis G. Alexandros
pleomorphic lipoblasts
Images – Pleomorphic lipoblasts in well-differentiated liposarcoma / WLS https://twitter.com/smlungpathguy/status/880612355159273473 https://twitter.com/JMGardnerMD/status/880707319407022081 See also lipoblasts from $Archeogenetics via Alexandros on Inoreader http://ift.tt/2s94U0r via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:02

Medicine Sfakianakis G. Alexandros
mandibular SCC
mandibular squamous cell carcinoma Images Mandible resection for squamous cell carcinoma https://twitter.com/JMGardnerMD/status/880603060191494149 See also mandibular tumors squamous cell carcinoma / SCC from $Archeogenetics via Alexandros on Inoreader http://ift.tt/2trNnV6 via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:02

Medicine Sfakianakis G. Alexandros
nodal metastasis of chondrosarcoma
Images Nodal metastasis of a chondrosarcoma https://twitter.com/BellaMicheleang/status/880101424767668225 See also nodal metastasis from $Archeogenetics via Alexandros on Inoreader http://ift.tt/2s9ibpS via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:02

Medicine Sfakianakis G. Alexandros
digestive duplication cysts
Images Duplication cyst in mesocolon / colonic duplication cyst https://twitter.com/steland011/status/879959512496603136 See also duplication cysts digestive duplication cysts from $Archeogenetics via Alexandros on Inoreader http://ift.tt/2trW8ih via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:02

Medicine Sfakianakis G. Alexandros
duplication cysts
Examples Duplication cyst in mesocolon / colonic duplication cyst https://twitter.com/steland011/status/879959512496603136 See also cysts digestive duplication cysts from $Archeogenetics via Alexandros on Inoreader http://ift.tt/2s8RNMU via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:02

Medicine Sfakianakis G. Alexandros
nodal pathology
pathology of the lymph node Pathology : nodal pathology / nodal histopathology nodal anomalies nodal lesional syndromes nodal diseases nodal tumors nodal lymphomas B-cell lymphomas T-cell lymphomas Open references Histopathology of the Lymph Nodes. Susan A. Elmore. 2006. doi:10.1080/01926230600964722….

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:01

Medicine Sfakianakis G. Alexandros
silicone foreign body reaction
silicone granuloma Images silicone granuloma / silicone foreign body reaction https://twitter.com/leilalangston/status/880248134726635520 See also silicone foreign body reaction from $Archeogenetics via Alexandros on Inoreader http://ift.tt/2s8RL7K via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:01

Medicine Sfakianakis G. Alexandros
hepatic amyloidosis
amyloidosis of the liver Images Extreme amyloidosis of the liver https://twitter.com/UTSW_GIpath/status/880182472805421056 See also amyloidosis / amyloidoses hepatic diseases hepatic anomalies from $Archeogenetics via Alexandros on Inoreader http://ift.tt/2trRAbt via IFTTT

medicine-alsfakia.blogspot.com?w=16&cs=4186838625
16:01

Medicine Sfakianakis G. Alexandros
disseminated pneumocystosis
disseminated Pneumocystis Images Lymph node in HIV+ male. Disseminated pneumocystis: No budding, No thick capsules. Very uniform cup-shaped organisms. https://twitter.com/hematogones/status/880190615484604417 Open references Disseminated pneumocystis carinii infection in AIDS. 1991. http://ift.tt/2ts4J4b...

iatrikisfakianakis.blogspot.com?w=16&cs=696837349
16:01

Ιατρικά Άρθρα Αλέξανδρος Γ. Σφακιανάκης
Pretransplant diabetes mellitus predicts worse outcomes of liver transplantation: evidence from meta-analysis
Abstract Background It has been demonstrated that the prognosis of liver transplantation (LT) is significantly influenced by pretransplant factors, such as diabetes mellitus (DM). However, inconsistent observations are obtained. Methods We comprehensively searched PubMed, Embase and Web of Science…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:01

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Stefan Lorenz Sorgner: Transhumanismus – ‘die gefährlichste Idee der Welt!?’
from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2sulHuo via IFTTT

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:01

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Being Seen: An Exploration of a Core Phenomenon of Human Existence and Its Normative Dimensions
Abstract This essay explores the nature of being visible and its normative dimensions. In a first part, core traits of an anthropology of visibility are sketched, drawing mainly on Hans Blumenberg’s phenomenological studies. In a second part, human visibility is investigated regarding its implications…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:01

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Tissue banking, biovigilance and the notify library
Abstract This issue is dedicated to the contributions of Professor Glyn O. Phillips to the field of tissue banking and the advancement of science in general. The use of ionizing radiation to sterilize medical products drew the interest of the International Atomic Energy Agency (IAEA). A meeting in 1976…

medicine-sfakianakis.blogspot.com?w=16&cs=3712665604
16:01

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Importante riconoscimento per gli studi sul tumore al seno
Il lavoro, pubblicato su Cellular Oncology, è tra i più importanti del 2016 per "Change the World, One Article at a Time". Tra gli autori anche Anna Villarini e Franco Berrino dell’INT from # All Medicine by Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2sYtJip...

otorhinolaryggologos.blogspot.com?w=16&cs=734127961
15:59

Head and Neck Medicine by Alexandros G.Sfakianakis
Effect of arginine on the growth and biofilm formation of oral bacteria
Publication date: October 2017Source:Archives of Oral Biology, Volume 82 Author(s): Xuelian Huang, Keke Zhang, Meng Deng, Robertus A.M. Exterkate, Chengcheng Liu, Xuedong Zhou, Lei Cheng, Jacob M. ten Cate BackgroundAlkali production via arginine deiminase system (ADS) of oral bacteria plays a significant…

otorhinolaryggologos.blogspot.com?w=16&cs=734127961
15:59

Head and Neck Medicine by Alexandros G.Sfakianakis
Topical application of ointment containing 0.5% green tea catechins suppresses tongue oxidative stress in 5-fluorouracil administered rats
Publication date: October 2017Source:Archives of Oral Biology, Volume 82 Author(s): Hisataka Miyai, Takayuki Maruyama, Takaaki Tomofuji, Toshiki Yoneda, Tetsuji Azuma, Hirofumi Mizuno, Yoshio Sugiura, Terumasa Kobayashi, Daisuke Ekuni, Manabu Morita ObjectiveThe purpose of this study was to investigate…

medicineasfakiakianakis.blogspot.com?w=16&cs=3822443964
15:57

Medicine by Sfakianakis G. Alexandros
Role of cervical vestibular evoked myogenic potentials (cVEMP) and auditory brainstem response (ABR) in the evaluation of vestibular schwannoma
Abstract Introduction: Cervical vestibular evoked myogenic potentials (cVEMP) can assess the integrity of the inferior vestibular nerve thereby promising to be a useful tool in the audiological test battery to diagnose vestibular schwannoma. Objective: To ascertain the utility of cVEMP in diagnosis of…

medsfakianakis.blogspot.com?w=16&cs=3897793244
15:57

Medicine by Sfakianakis Alexandros
A glycomics-based test predicts the development of hepatocellular carcinoma in cirrhosis
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iatriki-sfakianakis.blogspot.com?w=16&cs=815028064
15:57

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Diagnostic value of repeated Dix-Hallpike and roll maneuvers in benign paroxysmal positional vertigo
Abstract Introduction: Benign Paroxysmal Positional Vertigo (BPPV) is the most common peripheral vestibular disorder. The Dix-Hallpike and Roll maneuvers are used to diagnose BPPV. Objective: This study aims to investigate the diagnostic value of repeated Dix-Hallpike and Roll maneuvers in BPPV. Methods:…

iatriki-sfakianakis.blogspot.com?w=16&cs=815028064
15:57

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Correlation of the torsion values measured by rotational profile, kinematics, and CT study in CP patients
Publication date: September 2017Source:Gait & Posture, Volume 57Author(s): Ha Yong Kim, Yong Han Cha, Young Sub Chun, Hyuck Soo ShinBackgroundThe purpose of study was to analyze correlations between bony torsions measured by Staheli’s rotation profile, computed tomography (CT) torsional study, and…

iatriki-sfakianakis.blogspot.com?w=16&cs=815028064
15:57

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Acute otitis media in children: a vaccine-preventable disease?
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2stEYw8via IFTTT

iatriki-sfakianakis.blogspot.com?w=16&cs=815028064
15:57

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Sound generator associated with the counseling in the treatment of tinnitus: evaluation of the effectiveness
Abstract Introduction: The relations between the tinnitus and the hearing loss are due to the sensory deprivation caused by hearing loss, since this is followed by the functional and structural alteration of the auditory system as a whole. The cochlear lesions are accompanied by a reduction in the activity…

iatriki-sfakianakis.blogspot.com?w=16&cs=815028064
15:57

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Thyroid gland invasion in advanced squamous cell carcinoma of the larynx and hypopharynx,
Abstract Introduction: Squamous cell carcinoma of the larynx and hypopharynx has the potential to invade the thyroid gland. Despite this risk, the proposition of either partial or total thyroidectomy as part of the surgical treatment of all such cases remains controversial. Objectives: To evaluate the…

iatriki-sfakianakis.blogspot.com?w=16&cs=815028064
15:57

Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Difficult septal deviation cases: open or closed technique?
Abstract Introduction: The aim of this study is to compare the functional aspects of open technique (OTS) and endonasal septoplasty (ENS) in "difficult septal deviation cases". Methods: 60 patients with severe nasal obstruction from S-shaped deformities, multiple deformities, high deviations etc. were…